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HomeProduct name listCorosolic acid

Corosolic acid

Synonym(s):Corosolic acid;2α-Hydroxyursolic acid;Glucosol;Colosolic acid;(2α,3β)-2,3-Dihydroxyurs-12-en-28-oic acid

  • CAS NO.:4547-24-4
  • Empirical Formula: C30H48O4
  • Molecular Weight: 472.7
  • MDL number: MFCD06794973
  • EINECS: 610-253-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
Corosolic acid Structural

What is Corosolic acid?

Description

Corosolic acid is a triterpenoid that has been found in L. speciosa leaves and has diverse biological activities, including anticancer, anti-inflammatory, antidiabetic, antihypertensive, antihyperlipidemic, and antioxidant properties. It is cytotoxic to HepG2, A549, SNU-C4, HeLa S3, and K562 cells (EC50s = 4.8, 5, 0.4, 1, and 4.3 μg/ml, respectively). Corosolic acid inhibits ear edema in mice induced by phorbol 12-myristate 13-acetate (TPA; ) with an ID50 value of 0.09 mg/ear. It reduces blood glucose levels in an insulin tolerance test in a KKAy mouse model of type 2 diabetes when administered at doses of 2 and 10 mg/kg. Corosolic acid (0.072% in the diet) reduces systolic blood pressure and serum levels of free fatty acids, the oxidative stress markers thiobarbituric acid-reactive substances (TBARS) and 8-hydroxy-2’-deoxyguanosine (8-OHdG), and the myeloperoxidase markers 3-nitrotyrosine and 3-chlorotyrosine in an SHR/NDmcr-cp (cp/cp) rat model of metabolic syndrome.

The Uses of Corosolic acid

(2α,3β)-2,3-Dihydroxy-urs-12-en-28-oic Acid influences inflammatory gene expression regarding inflammatory bowel disease. In addition, its extracted from the plants Gentiana farreri and shows anti-tum or activity

The Uses of Corosolic acid

(2α,3β)-2,3-Dihydroxy-urs-12-en-28-oic Acid influences inflammatory gene expression regarding inflammatory bowel disease. In addition, its extracted from the plants Gentiana farreri and shows anti-tumor activity

Definition

ChEBI: A natural product found particularly in Rhododendron species and Eriobotrya japonica.

Properties of Corosolic acid

Melting point: 243~245℃
Boiling point: 573.3±50.0 °C(Predicted)
Density  1.14±0.1 g/cm3(Predicted)
storage temp.  2-8°C
solubility  methanol: soluble1mg/mL, clear, colorless
form  neat
pka 4.67±0.70(Predicted)
form  Solid
color  White
CAS DataBase Reference 4547-24-4(CAS DataBase Reference)

Safety information for Corosolic acid

Computed Descriptors for Corosolic acid

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