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HomeProduct name list3-ACETYL-11-KETO-BETA-BOSWELLIC ACID

3-ACETYL-11-KETO-BETA-BOSWELLIC ACID

Synonym(s):11-keto-β-Boswellic acid acetate;3α-Acetoxy-11-oxo-12-ursen-24-oic acid;3-O-Acetyl-11-keto-β-boswellic acid;AKBA

3-ACETYL-11-KETO-BETA-BOSWELLIC ACID Structural

What is 3-ACETYL-11-KETO-BETA-BOSWELLIC ACID?

Description

3-acetyl-11-keto-β-Boswellic acid is a naturally occurring pentacyclic triterpene isolated from the gum resin exudate from the stem of the tree B. serrata (frankincense). It selectively inhibits 5-lipoxygenase (IC50 = 1.5 μM) in an enzyme-directed, nonredox, and noncompetitive manner. 3-acetyl-11-keto-β-Boswellic acid and other members of the boswellic acid family have been studied for potential use in the control of inflammatory diseases, including arthritis and cancer.

The Uses of 3-ACETYL-11-KETO-BETA-BOSWELLIC ACID

3-Acetyl-11-keto-β-boswellic Acid (AKBA), be used in the place of the non-steroidal anti-inflammatory drug. AKBA, also inhibits human gastric carcinoma growth through modulation of the Wnt/β-catenin signaling pathway. It can be used as an anticancer agent.

What are the applications of Application

Acetyl-11-keto-β-Boswellic Acid, Boswellia serrata is a 5-LO and topo I and II inhibitor

Definition

ChEBI: 3-Acetyl-11-keto-beta-boswellic acid is a triterpenoid.

in vitro

akba exerted a time- and concentration -dependent cytotoxicity on androgen-independent prostate cancer cells. akba blocked proliferation and elicited apoptosis in the chemoresistant and androgen-independent human pc-3 prostate cancer cells by the release of mitochondrial cytochrome c and dna fragmentation. also, akba concentration-dependently inhibited nf-κb signaling, yet it did not directly affect the nf-κb binding to dna. additionally, akba suppressed inhibitor κb kinase and nf-κb-dependent antiapoptotic gene products in pc-3 cells [1].

in vivo

pc-3 xenotransplanted male nmri/nu-nu mice were injected intraperitoneally at 100 μmol/kg daily for three weeks. akba dampened growth and proliferation of pc-3 xenografts in nude mice and elicited apoptosis. moreover, compared with the control group, akba reduced the tumor volume and the invasiveness of the tumor into the surrounding tissues [1].

References

[1]. syrovets, t., gschwend, j., buchele, b., laumonnier, y., zugmaier, w., genze, f., & simmet, t. inhibition of iκb kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent pc-3 prostate cancer cells in vitro and in vivo. journal of biological chemistry. 2004; 280(7): 6170-6180.

Properties of 3-ACETYL-11-KETO-BETA-BOSWELLIC ACID

Melting point: 271℃
Boiling point: 600.3±55.0 °C(Predicted)
Density  1.13±0.1 g/cm3(Predicted)
storage temp.  Sealed in dry,Store in freezer, under -20°C
solubility  Chloroform (Sparingly), Methanol (Slightly)
form  neat
pka 4.28±0.70(Predicted)
form  Solid
color  White to Off-White

Safety information for 3-ACETYL-11-KETO-BETA-BOSWELLIC ACID

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 3-ACETYL-11-KETO-BETA-BOSWELLIC ACID

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