3-ACETYL-11-KETO-BETA-BOSWELLIC ACID
Synonym(s):11-keto-β-Boswellic acid acetate;3α-Acetoxy-11-oxo-12-ursen-24-oic acid;3-O-Acetyl-11-keto-β-boswellic acid;AKBA
- CAS NO.:67416-61-9
- Empirical Formula: C32H48O5
- Molecular Weight: 512.73
- MDL number: MFCD03788777
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is 3-ACETYL-11-KETO-BETA-BOSWELLIC ACID?
Description
3-acetyl-11-keto-β-Boswellic acid is a naturally occurring pentacyclic triterpene isolated from the gum resin exudate from the stem of the tree B. serrata (frankincense). It selectively inhibits 5-lipoxygenase (IC50 = 1.5 μM) in an enzyme-directed, nonredox, and noncompetitive manner. 3-acetyl-11-keto-β-Boswellic acid and other members of the boswellic acid family have been studied for potential use in the control of inflammatory diseases, including arthritis and cancer.
The Uses of 3-ACETYL-11-KETO-BETA-BOSWELLIC ACID
3-Acetyl-11-keto-β-boswellic Acid (AKBA), be used in the place of the non-steroidal anti-inflammatory drug. AKBA, also inhibits human gastric carcinoma growth through modulation of the Wnt/β-catenin signaling pathway. It can be used as an anticancer agent.
What are the applications of Application
Acetyl-11-keto-β-Boswellic Acid, Boswellia serrata is a 5-LO and topo I and II inhibitor
Definition
ChEBI: 3-Acetyl-11-keto-beta-boswellic acid is a triterpenoid.
in vitro
akba exerted a time- and concentration -dependent cytotoxicity on androgen-independent prostate cancer cells. akba blocked proliferation and elicited apoptosis in the chemoresistant and androgen-independent human pc-3 prostate cancer cells by the release of mitochondrial cytochrome c and dna fragmentation. also, akba concentration-dependently inhibited nf-κb signaling, yet it did not directly affect the nf-κb binding to dna. additionally, akba suppressed inhibitor κb kinase and nf-κb-dependent antiapoptotic gene products in pc-3 cells [1].
in vivo
pc-3 xenotransplanted male nmri/nu-nu mice were injected intraperitoneally at 100 μmol/kg daily for three weeks. akba dampened growth and proliferation of pc-3 xenografts in nude mice and elicited apoptosis. moreover, compared with the control group, akba reduced the tumor volume and the invasiveness of the tumor into the surrounding tissues [1].
References
[1]. syrovets, t., gschwend, j., buchele, b., laumonnier, y., zugmaier, w., genze, f., & simmet, t. inhibition of iκb kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent pc-3 prostate cancer cells in vitro and in vivo. journal of biological chemistry. 2004; 280(7): 6170-6180.
Properties of 3-ACETYL-11-KETO-BETA-BOSWELLIC ACID
Melting point: | 271℃ |
Boiling point: | 600.3±55.0 °C(Predicted) |
Density | 1.13±0.1 g/cm3(Predicted) |
storage temp. | Sealed in dry,Store in freezer, under -20°C |
solubility | Chloroform (Sparingly), Methanol (Slightly) |
form | neat |
pka | 4.28±0.70(Predicted) |
form | Solid |
color | White to Off-White |
Safety information for 3-ACETYL-11-KETO-BETA-BOSWELLIC ACID
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 3-ACETYL-11-KETO-BETA-BOSWELLIC ACID
Abamectin manufacturer
Ennature Biopharma (A Division of India Glycols Limited)
Sanovi Pharmaceuticals Pvt Ltd
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