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HomeProduct name listAluminon

Aluminon

Synonym(s):ATA;Aluminon;Aurintricarboxylic acid ammonium salt;Aurin tricarboxylic acid ammonium salt;Aluminon, Ammonium aurin tricarboxylate

  • CAS NO.:569-58-4
  • Empirical Formula: C22H17NO9
  • Molecular Weight: 439.38
  • MDL number: MFCD00040925
  • EINECS: 209-319-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-12-18 13:37:16
Aluminon Structural

What is Aluminon?

Chemical properties

dark red crystalline powder

The Uses of Aluminon

Aluminon can used as a reagent for aluminum in solution. It is also Forms brilliantly colored lakes with aluminum, chromium, iron, beryllium. Generally used for the detection and colorimetric estimation of aluminum in water, foods, tissues. Cf. Scherrer, Mogerman, J. Res. Natl. Bur. Stand. 21, 105 (1938).

The Uses of Aluminon

It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase C in PC12 cells. Aurintricarboxylic acid inhibits apoptosis in many cell types.

What are the applications of Application

Aurintricarboxylic acid ammonium salt is a free radical generating inhibitor of ribonuclease and topoisomerase II

Definition

ChEBI: An ammonium salt that is the ammonium salt of 3,3'-[(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methylene]bis(6-hydroxybenzoic acid). A dye commonly used to detect the presence of the aluminium ion in an aqueous solution.

Biochem/physiol Actions

Aurintricarboxylic acid readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase C in PC12 cells. Aurintricarboxylic acid inhibits apoptosis in many cell types. Its neuroprotective effect, perhaps due to its ability to prevent down-regulation of Ca2+ impermeable GluR2 receptors or to its ability to inhibit calpain, a Ca2+-activated protease that is activated during apoptosis.

Safety Profile

Human reproductive effects by ingestion: changes in male fertility. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NH3 and NOx,.

Properties of Aluminon

Melting point: 220-225 °C (dec.)(lit.)
Boiling point: 573.92°C (rough estimate)
Density  1.4414 (rough estimate)
refractive index  1.6300 (estimate)
storage temp.  room temp
solubility  DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 10 mg/ml,PBS (pH 7.2): 100 μg/ml
form  powder
Colour Index  43810
color  Deep red
PH 5.3 (10g/l, H2O, 20°C)
Water Solubility  800 g/L (20 ºC)
Merck  14,322
BRN  3900820
Stability: Stable.
CAS DataBase Reference 569-58-4
EPA Substance Registry System Benzoic acid, 5-[(3-carboxy-4-hydroxyphenyl)(3-carboxy-4-oxo-2,5-cyclohexadien-1-ylidene)methyl]-2-hydroxy-, triammonium salt (569-58-4)

Safety information for Aluminon

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P321:Specific treatment (see … on this label).
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for Aluminon

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