2-Oxetanone
Synonym(s):3-Hydroxypropionic acid lactone;Hydracrylic acid β-lactone;Oxetan-2-one
- CAS NO.:57-57-8
- Empirical Formula: C3H4O2
- Molecular Weight: 72.06
- MDL number: MFCD00005169
- EINECS: 200-340-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-22 18:05:02
What is 2-Oxetanone?
Toxicity
Based on experimental trials, it has been determined that propiolactone is a human carcinogen. The results have shown the generation of tumors in several tissues and from different administration routes.
Description
Beta-propiolactone is a colorless liquid with a strong, slightly
sweet odor. It may occur naturally, but no clear documentation
of its occurrence in nature was found, and it must be synthesized
for commercial purposes. Beta-propiolactone is unstable
at room temperature but stable when stored at 5 C in glass
containers.
Its tendency to be unstable and react with other molecules in
the vicinity is responsible for both its toxicity and its usefulness.
Significant commercial production of beta-propiolactone took
place during the late 1950s through the mid-1970s, when it was
widely used in chemical synthesis in reactions with other
molecules to produce new chemicals. All lactones are characterized
by a ring structure consisting of two or more carbon
atoms – as can be seen from its structure, beta-propiolactone
has three in its ring – and a single oxygen, coupled with an
adjacent ketone. The fewer the carbons in the ring, the more
‘strained’ is the ring structure and the more unstable and reactive
its characteristics. When the ring bonds break, the betapropiolactone
molecules attach to other nearby molecules.
The Uses of 2-Oxetanone
Reacts with bacteriphage DNA causing inactivation, repair and recombination
Indications
Propiolactone was used for vaccines, tissue grafts, surgical instruments, and enzymes, as a sterilant of blood plasma, water, milk and nutrient broth as a vapor-phase disinfectant in enclosed spaces. Its sporicidal action is used against vegetative bacteria, pathologic fungi, and viruses. It is no longer used in medical procedures or in food.
Background
Propiolactone is a lactone compound with a four-membered ring. It is a colorless liquid with a pungent slightly sweet odor. Propiolactone is a disinfectant used for the sterilization of blood plasma, vaccines, tissue grafts, surgical instruments, and enzymes. It has been used against bacteria, fungi, and virus. It is currently FDA approved for its use as an indirect additive used in food contact substances. Propiolactone was first commercially available in the United States in 1958.
Pharmacokinetics
When employed under conditions of maximum effectiveness, propiolactone is approximately 25 more active as a vapor phase disinfectant than formaldehyde, 4000 times more active than ethylene oxide and 50000 times more active than methyl bromide. It has been shown to be mutagenic by inducing cell transformation, chromosomal aberrations and chromatoid exchange. Propiolactone has been shown to be mutagenic in both somatic and germ cells.
Metabolism
Propiolactone is completely hydrolyzed after 3 hours of being in an aqueous solution and this time can be even faster in the presence of cellular debris and cell culture media. When in water, the lactone ring opens at the alkyl and acyl bonds. The degradation products of propiolactone are not toxic.
Properties of 2-Oxetanone
Melting point: | -33 °C (lit.) |
Boiling point: | 162 °C (lit.) |
Density | 1.146 g/mL at 25 °C (lit.) |
Flash point: | 158 °F |
storage temp. | -20°C |
solubility | Miscible with acetone, alcohol, chloroform, and ether (Windholz et al., 1983) |
form | Liquid |
color | Colorless liquid with a sweet but irritating odor |
Water Solubility | 37 g/100 mL |
Sensitive | Moisture Sensitive |
Safety information for 2-Oxetanone
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H330:Acute toxicity,inhalation H350:Carcinogenicity |
Precautionary Statement Codes |
P202:Do not handle until all safety precautions have been read and understood. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Oxetanone
InChIKey | VEZXCJBBBCKRPI-UHFFFAOYSA-N |
Abamectin manufacturer
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