Chemical Book India PDF
Chemical Safety Data Sheet MSDS / SDS

Propiolactone SDS

Revision Date:2024-04-25 Revision Number:1
Section 1 Section 2 Section 3 Section 4 Section 5 Section 6 Section 7 Section 8 Section 9 Section 10 Section 11 Section 12 Section 13 Section 14 Section 15 Section 16

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

  • Product name: Propiolactone
  • CAS: 57-57-8

Relevant identified uses of the substance or mixture and uses advised against

  • Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
  • Uses advised against: none

Company Identification

  • Company:Chemicalbook.in
  • Address:5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
  • Telephone:+91 9550333722

SECTION 2: Hazards identification

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Acute toxicity - Category 2, Inhalation

Carcinogenicity, Category 1B

GHS label elements, including precautionary statements

  • Pictogram(s)
  • Signal word Danger
Hazard statement(s)

H315 Causes skin irritation

H319 Causes serious eye irritation

H330 Fatal if inhaled

H350 May cause cancer

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

P284 [In case of inadequate ventilation] wear respiratory protection.

P203 Obtain, read and follow all safety instructions before use.

Response

P302+P352 IF ON SKIN: Wash with plenty of water/...

P321 Specific treatment (see ... on this label).

P332+P317 If skin irritation occurs: Get medical help.

P362+P364 Take off contaminated clothing and wash it before reuse.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P316 Get emergency medical help immediately.

P320 Specific treatment is urgent (see ... on this label).

P318 IF exposed or concerned, get medical advice.

Storage

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P405 Store locked up.

Disposal

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

SECTION 3: Composition/information on ingredients

Substance

  • Chemical name: Propiolactone
  • Common names and synonyms: Propiolactone
  • CAS number: 57-57-8
  • EC number: 200-340-1
  • Concentration: 100%

SECTION 4: First aid measures

Description of necessary first-aid measures

If inhaled

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

Following skin contact

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

Following eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Following ingestion

Rinse mouth. Do NOT induce vomiting. Refer for medical attention .

Most important symptoms/effects, acute and delayed

The toxicity potential of this material via inhalation or ingestion is high; may cause death or permanent injury after very short exposures to small quantities. It is a carcinogen. (EPA, 1998)

Indication of immediate medical attention and special treatment needed, if necessary

In the event of an emergency, remove the victim from further exposure, send for medical assistance, and initiate emergency procedures. If a worker had contact with beta-propiolactone, OSHA requires that that the worker shower as soon as possible, unless contraindicated by physical injuries.

SECTION 5: Firefighting measures

Suitable extinguishing media

Use alcohol foam.

Specific hazards arising from the chemical

Containers may explode. When heated to decomposition, it emits acrid smoke and fumes. Stable when stored at 41F. Avoid storing in areas of exposure to the direct rays of the sun and in areas of high fire hazard. Tends to polymerize on storage. Avoid elevated temperatures. (EPA, 1998)

Special protective actions for fire-fighters

Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Personal protection: self-contained breathing apparatus. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Environmental precautions

Personal protection: complete protective clothing including self-contained breathing apparatus. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Methods and materials for containment and cleaning up

PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. Chemical Carcinogens

SECTION 7: Handling and storage

Precautions for safe handling

NO open flames. Above 74°C use a closed system and ventilation. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Separated from food and feedstuffs. Cooled. Well closed. Ventilation along the floor.MATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMPOSE INTO TOXIC COMPONENTS ... SHOULD BE STORED IN A COOL WELL VENTILATED PLACE, OUT OF THE DIRECT RAYS OF THE SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, AND SHOULD BE PERIODICALLY INSPECTED. INCOMPATIBLE MATERIALS SHOULD BE ISOLATED .

SECTION 8: Exposure controls/personal protection

Control parameters

Occupational Exposure limit values

TLV: 0.5 ppm as TWA; A3 (confirmed animal carcinogen with unknown relevance to humans).MAK: skin absorption (H); carcinogen category: 2

Biological limit values

no data available

Appropriate engineering controls

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Wear safety goggles or eye protection in combination with breathing protection.

Skin protection

Protective gloves. Protective clothing.

Respiratory protection

Use ventilation, local exhaust or breathing protection.

Thermal hazards

no data available

SECTION 9: Physical and chemical properties and safety characteristics

  • Physical state:

    Beta-propiolactone is a colorless liquid with a slightly sweetish, pungent odor. Used as an intermediate in organic synthesis; disinfectant, sterilant for blood plasma, tissue grafts, vaccines, enzymes and surgical instruments. (EPA, 1998)

  • Colour:

    A COLORLESS LIQUID

  • Odour:

    PUNGENT

  • Melting point/freezing point:

    -12°C(lit.)

  • Boiling point or initial boiling point and boiling range:

    165°C(lit.)

  • Flammability:

    Class IIIA Combustible Liquid: Fl.P. at or above 140°F and below 200°F.

  • Lower and upper explosion limit/flammability limit:

    LOWER FLAMMABLE LIMIT: 2.9%

  • Flash point:

    74°C(lit.)

  • Auto-ignition temperature:

    no data available

  • Decomposition temperature:

    155°C

  • pH:

    no data available

  • Kinematic viscosity:

    no data available

  • Solubility:

    10 to 50 mg/mL at 66° F (NTP, 1992)

  • Partition coefficient n-octanol/water:

    log Kow= 0.462 (est)

  • Vapour pressure:

    3.4 mm Hg at 77° F (EPA, 1998)

  • Density and/or relative density:

    1.146

  • Relative vapour density:

    2.5 (NTP, 1992) (Relative to Air)

  • Particle characteristics:

    no data available

SECTION 10: Stability and reactivity

Reactivity

NIOSH considers beta-propiolactone to be a potential occupational carcinogen.

The substance may polymerize due to warming. This generates fire or explosion hazard.

Chemical stability

Stable when stored at +5 deg c in glass containers

Possibility of hazardous reactions

FIRE HAZARD: MODERATE, WHEN EXPOSED TO HEAT OR FLAME .BETA-PROPIOLACTONE is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. This chemical may be incompatible with alkalis.

Conditions to avoid

no data available

Incompatible materials

Acetates, halogens, thiocyanates, thiosulfates [Note: May polymerize upon storage].

Hazardous decomposition products

no data available

SECTION 11: Toxicological information

Acute toxicity

  • Oral: no data available
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

A3; Confirmed animal carcinogen with unknown relevance to humans.

Reproductive toxicity

No information is available on the reproductive or developmental effects of beta-propiolactone in humans or animals.

STOT-single exposure

The substance is severely irritating to the eyes. The substance is irritating to the skin and respiratory tract.

STOT-repeated exposure

This substance is probably carcinogenic to humans.

Aspiration hazard

A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C on spraying.

SECTION 12: Ecological information

Toxicity

  • Toxicity to fish: no data available
  • Toxicity to daphnia and other aquatic invertebrates: no data available
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

Persistence and degradability

no data available

Bioaccumulative potential

The rapid aqueous hyrolysis of beta-propiolactone precludes the importance of bioconcentration. (SRC)

Mobility in soil

The rapid aqueous hyrolylsis of beta-propiolactone precludes the importance of leaching. (SRC)

Other adverse effects

no data available

SECTION 13: Disposal considerations

Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

SECTION 14: Transport information

UN Number

ADR/RID: UN3382 (For reference only, please check.)

IMDG: UN3382 (For reference only, please check.)

IATA: UN3382 (For reference only, please check.)

UN Proper Shipping Name

ADR/RID: TOXIC BY INHALATION LIQUID, N.O.S. with an LC50 lower than or equal to 1000 ml/m3 and saturated vapour concentration greater than or equal to 10 LC50 (For reference only, please check.)

IMDG: TOXIC BY INHALATION LIQUID, N.O.S. with an LC50 lower than or equal to 1000 ml/m3 and saturated vapour concentration greater than or equal to 10 LC50 (For reference only, please check.)

IATA: TOXIC BY INHALATION LIQUID, N.O.S. with an LC50 lower than or equal to 1000 ml/m3 and saturated vapour concentration greater than or equal to 10 LC50 (For reference only, please check.)

Transport hazard class(es)

ADR/RID: 6.1 (For reference only, please check.)

IMDG: 6.1 (For reference only, please check.)

IATA: 6.1 (For reference only, please check.)

Packing group, if applicable

ADR/RID: I (For reference only, please check.)

IMDG: I (For reference only, please check.)

IATA: I (For reference only, please check.)

Environmental hazards

ADR/RID: No

IMDG: No

IATA: No

Special precautions for user

no data available

Transport in bulk according to IMO instruments

no data available

SECTION 15: Regulatory information

Safety, health and environmental regulations specific for the product in question

European Inventory of Existing Commercial Chemical Substances (EINECS)
Listed.
EC Inventory
Listed.
United States Toxic Substances Control Act (TSCA) Inventory
Listed.
China Catalog of Hazardous chemicals 2015
Not Listed.
New Zealand Inventory of Chemicals (NZIoC)
Listed.
(PICCS)
Not Listed.
Vietnam National Chemical Inventory
Not Listed.
IECSC)
Not Listed.
Korea Existing Chemicals List (KECL)
Listed.

SECTION 16: Other information

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any