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HomeProduct name listSTF-62247

STF-62247

Synonym(s):Autophagy Inducer, STF-62247 - CAS 315702-99-9 - Calbiochem;N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine

  • CAS NO.:315702-99-9
  • Empirical Formula: C15H13N3S
  • Molecular Weight: 267.35
  • MDL number: MFCD01121974
  • EINECS: 631-141-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-08 20:21:46
STF-62247 Structural

What is STF-62247?

Description

STF-62247 (315702-99-9) specifically induces autophagic cell death in VHL (von Hippel-Lindau)-deficient renal carcinoma cells both in vitro (IC50=625 nM) and in vivo. Renal cell carcinoma cell lines were radiosensitized by induction of autophagy following treatment with STF-62247. Cell permeable

The Uses of STF-62247

Autophagy Inducer, STF-62247 is selectively kills RCC cells that have lost VHL tumor suppressor activity.

What are the applications of Application

Autophagy Inducer, STF-62247 is selectively kills RCC cells that have lost VHL tumor suppressor activity

Definition

ChEBI: N-(3-methylphenyl)-4-pyridin-4-yl-2-thiazolamine is a substituted aniline.

in vitro

in vitro study demonstrated that stf-62247 exhibited selectively cytotoxicity and tumor growth inhibitory activity towards wild-type vhl and vhl-deficient renal cell carcinoma (rcc) in a hif-independent manner with ic50 of 16 μm and 0.625 μm, respectively. in addion, stf-62247 also resulted in cell apoptosis by inducing acidification and increasing autophagy in vhl-deficient cells. [1]

in vivo

animal experiments for stf-62247 activity were performed according to institutional and national guidelines and approved by stanford university's administrative panel on laboratory animal care. based on an in vivo mouse model, it was found that intraperitoneal injection of stf-62247 at a dose of 8 mg/kg significantly inhibited tumor growth of vhl-deficient sn12c tumor cells. [1]

References

1) Turcotte et al. (2008), Targeted therapy for the loss of von Hippel-Lindau in renal cell carcinoma: a novel molecule that induces autophagic cell death; Autophagy, 4 944 2) Chan et al. (2008), Targeting cancer cells by synthetic lethality: autophagy and VHL in cancer therapeutics; Cell Cycle, 7 2987 3) Anbalagan et al. (2012), Radiosensitization of renal cell carcinoma in vitro through the induction of autophagy; Radiother. Oncol., 103 388

Properties of STF-62247

Melting point: 158-160℃
Density  1.255
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
solubility  DMSO: soluble26mg/mL
form  solid
color  Off-white
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Safety information for STF-62247

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H413:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P273:Avoid release to the environment.
P501:Dispose of contents/container to..…

Computed Descriptors for STF-62247

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