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HomeProduct name listLY 294002 HYDROCHLORIDE

LY 294002 HYDROCHLORIDE

Synonym(s):2-(4-Morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride;2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor IV, BRD3 Inhibitor III, BRD4 Inhibitor IV;PI3K inhibitor;

  • CAS NO.:154447-36-6
  • Empirical Formula: C19H17NO3
  • Molecular Weight: 307.34
  • MDL number: MFCD01530034
  • EINECS: 1312995-182-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 21:24:55
LY 294002 HYDROCHLORIDE Structural

What is LY 294002 HYDROCHLORIDE?

Description

LY294002 is a selective phosphatidylinositol 3-kinase (PI3K) inhibitor with a 2.7-fold greater potency than quercetin. LY294002 inhibits purified PI3K with an IC50 of 1.4 μM.

The Uses of LY 294002 HYDROCHLORIDE

LY 294002 Hydrochloride is a highly selective inhibitor of Phosphatidylinositol 3-kinase (PI3K). It is a salt analogue of LY 294002 (L486590).

The Uses of LY 294002 HYDROCHLORIDE

A potent blocker of PI 3-kinase/Akt signaling.

The Uses of LY 294002 HYDROCHLORIDE

LY294002 is a selective phosphatidylinositol 3-kinase (PI3K) inhibitor with a 2.7-fold greater potency than quercetin. LY294002 inhibits purified PI3K with an IC50 of 1.4 μM.

The Uses of LY 294002 HYDROCHLORIDE

LY 294002 is a Phosphatidylinositol 3-kinase (PI3K) inhibitor which has shown to block the formation of tumor tissues in bone marrow cavity an abolish multiple myeloma (MM) induced osteoclast formation and osteolysis in SCID mice.

Definition

ChEBI: A chromone substituted with a phenyl group at position 8 and a morpholine group at position 2.

What are the applications of Application

LY 294002 is a potent blocker of PI 3-kinase/Akt signaling

Biological Activity

A highly selective inhibitor of phosphatidylinositol 3-kinase (IC 50 values are 0.31, 0.73, 1.06 and 6.60 μ M for PI3K β , PI3K α , PI3K δ and PI3K γ respectively). Inhibits proliferation and induces apoptosis in human colon cancer cells in vitro and in vivo .

References

1) Vlahos et al. (1994) A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY 294002); J. Biol. Chem., 269 5241

Properties of LY 294002 HYDROCHLORIDE

Melting point: 183-185℃
Boiling point: 494.6±45.0 °C(Predicted)
Density  1.266
storage temp.  Sealed in dry,Store in freezer, under -20°C
solubility  DMSO: >5 mg/mL
form  solid
pka 0.55±0.20(Predicted)
color  white to off-white
Water Solubility  Soluble in DMSO at 5mg/ml. Insoluble in water
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months.
CAS DataBase Reference 154447-36-6

Safety information for LY 294002 HYDROCHLORIDE

Signal word Danger
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
GHS Hazard Statements H302:Acute toxicity,oral
H320:Serious eye damage/eye irritation
H336:Specific target organ toxicity,single exposure; Narcotic effects
H361:Reproductive toxicity
H370:Specific target organ toxicity, single exposure
H372:Specific target organ toxicity, repeated exposure
H402:Hazardous to the aquatic environment, acute hazard
Precautionary Statement Codes P201:Obtain special instructions before use.
P202:Do not handle until all safety precautions have been read and understood.
P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P271:Use only outdoors or in a well-ventilated area.
P273:Avoid release to the environment.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313:IF eye irritation persists: Get medical advice/attention.
P405:Store locked up.
P403+P233:Store in a well-ventilated place. Keep container tightly closed.

Computed Descriptors for LY 294002 HYDROCHLORIDE

InChIKey CZQHHVNHHHRRDU-UHFFFAOYSA-N

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