LY 294002 HYDROCHLORIDE

Synonym(s):2-(4-Morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride;2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor IV, BRD3 Inhibitor III, BRD4 Inhibitor IV;PI3K inhibitor;

CAS NO.：154447-36-6
Empirical Formula: C19H17NO3
Molecular Weight: 307.34
MDL number: MFCD01530034
EINECS: 1312995-182-4
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 20:33:22

What is LY 294002 HYDROCHLORIDE?

Description

LY294002 is a selective phosphatidylinositol 3-kinase (PI3K) inhibitor with a 2.7-fold greater potency than quercetin. LY294002 inhibits purified PI3K with an IC₅₀ of 1.4 μM.

The Uses of LY 294002 HYDROCHLORIDE

LY 294002 Hydrochloride is a highly selective inhibitor of Phosphatidylinositol 3-kinase (PI3K). It is a salt analogue of LY 294002 (L486590).

The Uses of LY 294002 HYDROCHLORIDE

A potent blocker of PI 3-kinase/Akt signaling.

The Uses of LY 294002 HYDROCHLORIDE

LY294002 is a selective phosphatidylinositol 3-kinase (PI3K) inhibitor with a 2.7-fold greater potency than quercetin. LY294002 inhibits purified PI3K with an IC50 of 1.4 μM.

The Uses of LY 294002 HYDROCHLORIDE

LY 294002 is a Phosphatidylinositol 3-kinase (PI3K) inhibitor which has shown to block the formation of tumor tissues in bone marrow cavity an abolish multiple myeloma (MM) induced osteoclast formation and osteolysis in SCID mice.

Definition

ChEBI: A chromone substituted with a phenyl group at position 8 and a morpholine group at position 2.

What are the applications of Application

LY 294002 is a potent blocker of PI 3-kinase/Akt signaling

Biological Activity

A highly selective inhibitor of phosphatidylinositol 3-kinase (IC 50 values are 0.31, 0.73, 1.06 and 6.60 μ M for PI3K β , PI3K α , PI3K δ and PI3K γ respectively). Inhibits proliferation and induces apoptosis in human colon cancer cells in vitro and in vivo .

References

1) Vlahos et al. (1994) A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY 294002); J. Biol. Chem., 269 5241

Properties of LY 294002 HYDROCHLORIDE

Melting point:	183-185℃
Boiling point:	494.6±45.0 °C(Predicted)
Density	1.266
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	DMSO: >5 mg/mL
form	solid
pka	0.55±0.20(Predicted)
color	white to off-white
Water Solubility	Soluble in DMSO at 5mg/ml. Insoluble in water
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months.
CAS DataBase Reference	154447-36-6

Safety information for LY 294002 HYDROCHLORIDE

Signal word	Danger
Pictogram(s)	Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H302:Acute toxicity,oral H320:Serious eye damage/eye irritation H336:Specific target organ toxicity,single exposure; Narcotic effects H361:Reproductive toxicity H370:Specific target organ toxicity, single exposure H372:Specific target organ toxicity, repeated exposure H402:Hazardous to the aquatic environment, acute hazard
Precautionary Statement Codes	P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed.