NPPB

Synonym(s):5-Nitro-2-(3-phenylpropylamino)benzoic Acid - CAS 107254-86-4 - Calbiochem;NPPB;NPPB, CaCC Blocker II, Calcium-Activated, TMEM16 Blocker II, ANO Blocker II, Anoctamin Blocker II

CAS NO.：107254-86-4
Empirical Formula: C16H16N2O4
Molecular Weight: 300.31
MDL number: MFCD00153851
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-28 16:48:35

What is NPPB?

The Uses of NPPB

NPPB is a chloride channel blocker and acts as a GPR35 agonist. It maintains protonophoric activity and has been used to uncouple mitochondrial ATP synthesis in phagocytes.

The Uses of NPPB

Biochemical probe primarily as a Cl- channel blocker.

What are the applications of Application

5-Nitro-2-(3-phenylpropylamino)benzoic Acid (NPPB) is a Cox inhibitor and GPR35 activator

Definition

ChEBI: 5-Nitro-2-(3-phenylpropylamino)benzoic acid is a nitrobenzoic acid.

Biological Activity

Very potent chloride channel blocker.

Biochem/physiol Actions

Potent chloride channel blocker.

storage

Store at RT

Properties of NPPB

Melting point:	178-180℃
Boiling point:	523.5±50.0 °C(Predicted)
Density	1.323±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	ethanol: 3 mg/mL
form	Yellow solid
pka	2.27±0.22(Predicted)
color	Light yellow to yellow

Safety information for NPPB

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.