CHLOROTOXIN
- CAS NO.：163515-35-3
- Empirical Formula: C158H249N53O47S11
- Molecular Weight: 3995.70956
- MDL number: MFCD08459453
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:06
What is CHLOROTOXIN?
Description
Chlorotoxin, a relatively small (36–amino acid) peptide is what makes the venom of the deathstalker scorpion (Leiurus quinquestriatus) poisonous. In 1991, J. A. DeBin and G. R. Strichartz at Harvard Medical School discovered that its mode of toxicity is to block small-conductance chloride channels, which results in paralysis.
Chlorotoxin preferentially binds to glioma cells, which prompted researchers to investigate it as a tool for diagnosing and treating some cancers. Building upon much of this research, J. M. Olson at Fred Hutchinson Cancer Center (Seattle) discovered a way to use chlorotoxin to image cancer cells—a product he calls Tumor Paint. An unusual aspect of Olson’s work is that he funded it via crowdsourcing when he couldn’t obtain grant money through the normal channels.
The Uses of CHLOROTOXIN
Biochemical probe for voltage-gated chloride channels.
Properties of CHLOROTOXIN
| storage temp. | −20°C |
| solubility | aqueous buffer: soluble |
| form | lyophilized powder |
| color | Colorless to light yellow |
Safety information for CHLOROTOXIN
Computed Descriptors for CHLOROTOXIN
New Products
2,2-diethoxyethanethioamide Tubulysin A (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin C Potassium HMDS (1.0 M in THF) Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- Cyclobutanamine, 3,3-difluoro- (9CI) 3-METHYLAZETIDIN-3-OL HYDROCHLORIDE 2,2,6,6-tetramethyl-2H-3,5,6-trihydropyran-4-one tetrahydro-4-methyl-2H-pyran 3,3-Difluoropyrrolidine (6-Nitro-2,3- dichlorobenzylamino) acetic acid ethylester.HCl (S)-3-(3-fluoro- 4-thiomorpholinophenyl) -4-(hydroxymethyl) oxazolidin-2-one 5-(piperazin-1-yl) benzofuran-2- carboxamide Lubiprostone Latanoprostene Bunod Magnesium Trisilicate 7-Methoxyquinoline-4-carboxylic acid 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carbonitrile (2R,3S)-2-Azido-3-methylpentanoic acid (R)-methyl 2-isocyano-3-(tritylthio)propanoate Ethinylestradiol EP Impurity J/1-Methyl Ethynyl Estradiol FUSIDIC ACID EP IMPURITY I / FUSIDIC ACID BP IMPURITY I / FUS 16-EPI-DEACETYL FUSIDIC ACIDRelated products of tetrahydrofuran
You may like
-
Chlorotoxin from Leiurus quinquestriatus (north Africa) CAS 163515-35-3View Details
163515-35-3 -
ethyl 2-formylthiazole-4-carboxylate 73956-17-9 99%View Details
73956-17-9 -
Tubulysin D 99%View Details
309935-57-7 -
Methyl (2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoate 58885-35-1 99%View Details
58885-35-1 -
(R)-methyl 2-isocyano-3-(tritylthio)propanoate 99%View Details
-
Tubulysin G 99%View Details
799822-08-5 -
205304-87-6 Tubulysin B 99%View Details
205304-87-6 -
205304-86-5 99%View Details
205304-86-5