N-Phenylanthranilic acid

Synonym(s):2-(Phenylamino)benzoic acid;Diphenylamine-2,2′-dicarboxylic acid;Diphenylamine-2-carboxylic acid;DpC;N-Phenylanthranilic acid

CAS NO.：91-40-7
Empirical Formula: C13H11NO2
Molecular Weight: 213.23
MDL number: MFCD00002421
EINECS: 202-066-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-07 13:31:19

What is N-Phenylanthranilic acid?

Chemical properties

LIGHT GREY-GREEN TO YELLOW-GREEN FINE POWDER

The Uses of N-Phenylanthranilic acid

N-Phenylanthranilic acid is used in biological studies for inhibitors of aldo-keto reductase 1C3 based on N-phenyl-aminobenzoates.

The Uses of N-Phenylanthranilic acid

ion channel (Cl) blocker

The Uses of N-Phenylanthranilic acid

Detection of vanadium in steel.

What are the applications of Application

Fenamic acid is a potent, non-specific blocker of Cl- channel and chloride-bicarbonate exchange

Definition

ChEBI: An aminobenzoic acid that is the N-phenyl derivative of anthranilic acid. It acts as a parent skeleton for the synthesis of several non-steroidal anti-inflammatory drugs.

Safety Profile

Poison by intravenous and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

Crystallise the acid from EtOH (5mL/g) or AcOH (2mL/g) by adding hot water (1mL/g). [Beilstein 14 IV 1019.]

Properties of N-Phenylanthranilic acid

Melting point:	182-185 °C (lit.)
Boiling point:	353.22°C (rough estimate)
Density	1.1544 (rough estimate)
refractive index	1.5700 (estimate)
storage temp.	Store below +30°C.
solubility	DMSO: 125 mg/mL (586.22 mM)
form	Fine Powder
pka	pKa 5.28(5–10%aq. acetone t=25±0.1 I=0.11) (Uncertain)
color	Light gray-green
Water Solubility	insoluble
Merck	14,7273
BRN	1456607
CAS DataBase Reference	91-40-7(CAS DataBase Reference)
EPA Substance Registry System	Phenylanthranilic acid (91-40-7)

Safety information for N-Phenylanthranilic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.