Clopamide
Synonym(s):4-Chloro-N-(2,6-dimethylpiperidinyl)-3-sulfamoylbenzamide
- CAS NO.:636-54-4
- Empirical Formula: C14H20ClN3O3S
- Molecular Weight: 345.84
- MDL number: MFCD00941495
- EINECS: 211-261-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is Clopamide?
Chemical properties
White or almost white, hygroscopic, crystalline powder
Originator
Brinaldix,Novartis
The Uses of Clopamide
Clopamide is a thiazide-like diuretic that inhibits sodium/chloride cotransporters in the proximal convoluted tubule of the kidney, which prevents the reabsorption of sodium and chloride. This compound is intended for research purposes only.
The Uses of Clopamide
Antihypertensive; diuretic.
The Uses of Clopamide
Antihypertensor;Gonad stimuling agent
What are the applications of Application
Clopamide is a compound that selectively inhibit the sodium chloride cotransporter
Definition
ChEBI: 4-chloro-N-[(2S,6R)-2,6-dimethyl-1-piperidinyl]-3-sulfamoylbenzamide is a sulfonamide.
Manufacturing Process
To a solution of 5.5 g of 3-chlorsulfonyl-4-chlorobenzoylchloride in 20 ml chlorobenzole 3.3 g of 1-amino-cis-2,6-dimethylpiperidin-hydrochloride slowly was added at room temperature. Reaction mixture was heated to 100°-105°C during 8 h, then it was cooled to room temperature. The precipitated crystals of N-[cis-2,6-dimethyl-piperidyl-(1)]-3-chlorsulfonyl-4-chlorobenzoylamide were filtered and dried at 100°C under vacuo, then was treated by ammonium at room temperature. The obtained product was chromatographed (aluminum oxide; eluent: chloroform-methanol 9:1 and methanol-ether) to give N-[cis- 2,6-dimethylpiperidyl-(1)]-3-sulfamyl-4-chlorbenzoylamide, melting point 235°-237°C.
brand name
Aquex (Novartis).
Therapeutic Function
Diuretic, Antihypertensive
Properties of Clopamide
Melting point: | 248-249℃ |
Density | 1.39±0.1 g/cm3(Predicted) |
RTECS | CV2338875 |
storage temp. | 2-8°C |
solubility | Chloroform (Slightly, Heated, Sonicated), Methanol (Slightly) |
form | neat |
pka | 9.41±0.60(Predicted) |
form | Solid |
color | Pale Yellow to Light Yellow |
CAS DataBase Reference | 636-54-4(CAS DataBase Reference) |
EPA Substance Registry System | Benzamide, 3-(aminosulfonyl)-4-chloro-N-[(2R,6S)-2,6-dimethyl-1-piperidinyl]-, rel- (636-54-4) |
Safety information for Clopamide
Signal word | Danger |
Pictogram(s) |
Health Hazard GHS08 |
GHS Hazard Statements |
H317:Sensitisation, Skin H334:Sensitisation, respiratory |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P284:Wear respiratory protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P342+P311:IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
Computed Descriptors for Clopamide
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Mefenamic Acid IP/BP/EP/USP Diclofenac Sodium IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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