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HomeProduct name listClopamide

Clopamide

Synonym(s):4-Chloro-N-(2,6-dimethylpiperidinyl)-3-sulfamoylbenzamide

  • CAS NO.:636-54-4
  • Empirical Formula: C14H20ClN3O3S
  • Molecular Weight: 345.84
  • MDL number: MFCD00941495
  • EINECS: 211-261-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
Clopamide Structural

What is Clopamide?

Chemical properties

White or almost white, hygroscopic, crystalline powder

Originator

Brinaldix,Novartis

The Uses of Clopamide

Clopamide is a thiazide-like diuretic that inhibits sodium/chloride cotransporters in the proximal convoluted tubule of the kidney, which prevents the reabsorption of sodium and chloride. This compound is intended for research purposes only.

The Uses of Clopamide

Antihypertensive; diuretic.

The Uses of Clopamide

Antihypertensor;Gonad stimuling agent

What are the applications of Application

Clopamide is a compound that selectively inhibit the sodium chloride cotransporter

Definition

ChEBI: 4-chloro-N-[(2S,6R)-2,6-dimethyl-1-piperidinyl]-3-sulfamoylbenzamide is a sulfonamide.

Manufacturing Process

To a solution of 5.5 g of 3-chlorsulfonyl-4-chlorobenzoylchloride in 20 ml chlorobenzole 3.3 g of 1-amino-cis-2,6-dimethylpiperidin-hydrochloride slowly was added at room temperature. Reaction mixture was heated to 100°-105°C during 8 h, then it was cooled to room temperature. The precipitated crystals of N-[cis-2,6-dimethyl-piperidyl-(1)]-3-chlorsulfonyl-4-chlorobenzoylamide were filtered and dried at 100°C under vacuo, then was treated by ammonium at room temperature. The obtained product was chromatographed (aluminum oxide; eluent: chloroform-methanol 9:1 and methanol-ether) to give N-[cis- 2,6-dimethylpiperidyl-(1)]-3-sulfamyl-4-chlorbenzoylamide, melting point 235°-237°C.

brand name

Aquex (Novartis).

Therapeutic Function

Diuretic, Antihypertensive

Properties of Clopamide

Melting point: 248-249℃
Density  1.39±0.1 g/cm3(Predicted)
RTECS  CV2338875
storage temp.  2-8°C
solubility  Chloroform (Slightly, Heated, Sonicated), Methanol (Slightly)
form  neat
pka 9.41±0.60(Predicted)
form  Solid
color  Pale Yellow to Light Yellow
CAS DataBase Reference 636-54-4(CAS DataBase Reference)
EPA Substance Registry System Benzamide, 3-(aminosulfonyl)-4-chloro-N-[(2R,6S)-2,6-dimethyl-1-piperidinyl]-, rel- (636-54-4)

Safety information for Clopamide

Signal word Danger
Pictogram(s)
ghs
Health Hazard
GHS08
GHS Hazard Statements H317:Sensitisation, Skin
H334:Sensitisation, respiratory
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P284:Wear respiratory protection.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.
P342+P311:IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

Computed Descriptors for Clopamide

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