L-2-Aminoadipic acid
Synonym(s):(S)-2-Aminohexanedioic acid;L -Homoglutamic acid;Aad
- CAS NO.：1118-90-7
- Empirical Formula: C6H11NO4
- Molecular Weight: 161.16
- MDL number: MFCD00002636
- EINECS: 601-134-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-22 13:59:06
What is L-2-Aminoadipic acid?
Chemical properties
WHITE SOLID
The Uses of L-2-Aminoadipic acid
L-2-Aminoadipic acid is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals.
The Uses of L-2-Aminoadipic acid
An inhibitor of ischemic glutamate release
What are the applications of Application
L-α-Aminoadipic acid is an inhibitor of ischemic glutamate release
Definition
ChEBI: The L-enantiomer of 2-aminoadipic acid.
General Description
L-2-Aminoadipic acid/α-aminoadipate is a gliotoxin and is a structural analog of glutamine. It is generated by the catabolism of lysine saccharopine (SAC)/pipecolic acid (PIP) pathways.
Biochem/physiol Actions
L-2-Aminoadipic acid inhibits glutamine synthetase and γ-glutamylcysteine synthetase. It modulates glucose metabolism and is present in higher levels in diabetic patients. L-2-Aminoadipic acid plays a key role in suppressing autophagy in C2C12 myotubes.
Properties of L-2-Aminoadipic acid
| Melting point: | 203-205 °C (dec.)(lit.) |
| Boiling point: | 287.44°C (rough estimate) |
| alpha | 22 º (c=2, 5 N HCl 25 ºC) |
| Density | 1.3482 (rough estimate) |
| refractive index | 1.4230 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | 1N HCl: 10 mg/ml; PBS (pH 7.2): 0.5 mg/ml |
| pka | 2.49±0.24(Predicted) |
| form | Solid |
| color | White |
| Water Solubility | Soluble in 1N HCl (50 mg/ml) and water (slightly). |
| BRN | 1724348 |
| CAS DataBase Reference | 1118-90-7(CAS DataBase Reference) |
Safety information for L-2-Aminoadipic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for L-2-Aminoadipic acid
| InChIKey | OYIFNHCXNCRBQI-BYPYZUCNSA-N |
L-2-Aminoadipic acid manufacturer
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