DL-Norvaline

Synonym(s):DL-Norvaline;Norval;(±)-2-Aminopentanoic acid;DL-2-aminopentanoic acid;DL-nor-Val

CAS NO.：760-78-1
Empirical Formula: C5H11NO2
Molecular Weight: 117.15
MDL number: MFCD00064420
EINECS: 212-082-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-09 21:40:10

What is DL-Norvaline?

Chemical properties

white to off-white crystals or crystalline powder

The Uses of DL-Norvaline

DL-Norvaline is a neurotransmitter.

The Uses of DL-Norvaline

DL-Norvaline has been used as an internal standard:

to analyze metabolites in cultured mammalian cells by gas chromatography-mass spectrometry (GC-MS)
to convert cysteine and cystine to Cys MPA (S-2-carboxyethylthio-L-cysteine) and quantify the same using a high-performance liquid chromatography (HPLC) analyzer
for free amino acid analysis in samples of oocytes by liquid chromatography

Definition

ChEBI: An alpha-amino acid that is valeric acid which is substituted at position 2 by an amino group.

General Description

DL-Norvaline, a non-protein amino acid, is of significance in metabolic pathways. It is used as a food additive on account of its nutritional and functional characteristics that are beneficial to health.

Biochem/physiol Actions

Norvaline mediates physiological and pathophysiological processes promoting nitric oxide production. It is used to treat Alzheimer′s disease and is effective against artificial metabolic syndrome in rats. Norvaline exhibits phase transition upon cooling below 190 K and hence it is useful in molecular machines. DL-Norvaline serves as a prototype for research in polymorphism and molecular dynamics of aliphatic α-amino acids containing linear side-chain. It influences the activity, stability, and side-chain packaging of proteins.

Properties of DL-Norvaline

Melting point:	≥300 °C (dec.)
Boiling point:	222.9±23.0 °C(Predicted)
Density	1.2000 (estimate)
refractive index	1.4650 (estimate)
storage temp.	Store below +30°C.
solubility	83.9g/l
form	Solid
pka	2.36, 9.72(at 25℃)
color	White to Off-White
optical activity	[α]25/D 0.00±0.10°, c = 2 in 5 M HCl
Water Solubility	1 g/10 mL (18 ºC)
Merck	14,6716
BRN	1721163
CAS DataBase Reference	760-78-1(CAS DataBase Reference)
NIST Chemistry Reference	(Dl) 2-aminopentanoic acid(760-78-1)
EPA Substance Registry System	Norvaline (760-78-1)

Safety information for DL-Norvaline

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.