D(+)-Ribonic acid gamma-lactone
Synonym(s):D(+)-Ribono-1,4-lactone
- CAS NO.：5336-08-3
- Empirical Formula: C5H8O5
- Molecular Weight: 148.11
- MDL number: MFCD00063241
- EINECS: 226-256-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-05 08:26:49
What is D(+)-Ribonic acid gamma-lactone?
Chemical properties
White Crystalline Solid
The Uses of D(+)-Ribonic acid gamma-lactone
Important chiral synthon
The Uses of D(+)-Ribonic acid gamma-lactone
A sugar lactone as inhibitor of β-galactosidase of E. coli.
The Uses of D(+)-Ribonic acid gamma-lactone
D-ribono-1,4-lactone is a compound useful in organic synthesis.
What are the applications of Application
D-Ribonolactone is a sugar lactone and β-galactosidase inhibitor
Definition
ChEBI: A five-membered form of ribonolactone having D-configuration.
Purification Methods
Purify D-(+)-ribonic acid--lactone by recrystallisation from EtOAc. The tribenzoate has m 54-56o (from AcOH), [] D 25 +27o (c 2.37, Me2NCHO), and the 3,5-O-benzylidene derivative has m 230-231.5o (needles from Me2CO-pet ether) and [] D 25 -177o (CHCl3). [Chen & Joulié J Org Chem 49 2168 1984, Zinner & Voigt J Carbohydr Research 7 38 1968.]
Properties of D(+)-Ribonic acid gamma-lactone
| Melting point: | 85-87 °C(lit.) |
| Boiling point: | 188.68°C (rough estimate) |
| alpha | 18 º (c=5, H2O) |
| Density | 1.2336 (rough estimate) |
| refractive index | 18 ° (C=1, H2O) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | H2O: 0.1 g/mL, clear |
| form | Powder |
| pka | 12.10±0.60(Predicted) |
| color | White to Pale Yellow |
| optical activity | [α]24/D +18°, c = 1 in H2O |
| Water Solubility | soluble |
| BRN | 82057 |
| Stability: | Stable |
| CAS DataBase Reference | 5336-08-3(CAS DataBase Reference) |
| NIST Chemistry Reference | D-(+)-Ribonic acid gamma-lactone(5336-08-3) |
Safety information for D(+)-Ribonic acid gamma-lactone
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for D(+)-Ribonic acid gamma-lactone
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