D(+)-Pipecolinic acid

Synonym(s):(R)-(+)-2-Piperidinecarboxylic acid;(R)-Piperidine-2-carboxylic acid;(S)-(−)-2-Piperidinecarboxylic acid;D-Homoproline;L-Homoproline

CAS NO.：1723-00-8
Empirical Formula: C6H11NO2
Molecular Weight: 129.16
MDL number: MFCD00064346
EINECS: 217-024-4
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-06 19:41:26

What is D(+)-Pipecolinic acid?

Chemical properties

white to light yellow crystal powder

The Uses of D(+)-Pipecolinic acid

Pipecolic acid is involved in synaptic transmission in the central nervous system.

Definition

ChEBI: D-pipecolic acid is the D-enantiomer of pipecolic acid. It has a role as a human metabolite. It is a conjugate base of a D-pipecolate. It is an enantiomer of a L-pipecolic acid.

Purification Methods

D-Pipecolinic acid recrystallises as platelets from EtOH and is soluble in H2O. The hydrochloride has m 256-257o(dec) from H2O and [] D25 +10.8o (c 2, H2O). [cf p 422, Lukés et al. Collect Czech Chem Commun 22 286 1957, Bayerman Recl Trav Chim Pays-Bas 78 134 1959, Asher et al. Tetrahedron Lett 22 141 1981, Beilstein 22/1 V 220.]

Properties of D(+)-Pipecolinic acid

Melting point:	272 °C(lit.)
Boiling point:	239.22°C (rough estimate)
alpha	26.5 º (c=5,water 25 ºC)
Density	1.1426 (rough estimate)
refractive index	1.4300 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly)
form	Crystalline Powder
pka	2.28(at 25℃)
color	White to off-white
optical activity	[α]25/D +27°, c = 1 in H2O
Water Solubility	soluble
BRN	81094
CAS DataBase Reference	1723-00-8(CAS DataBase Reference)

Safety information for D(+)-Pipecolinic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.