CO-1686
- CAS NO.:1374640-70-6
- Empirical Formula: C27H28F3N7O3
- Molecular Weight: 555.55
- MDL number: MFCD26793864
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 09:03:09
What is CO-1686?
Description
CO-1686 is an irreversible kinase inhibitor that specifically targets mutant forms of the epidermal growth factor receptor (EGFR) including T790M (Ki = 21.5 nM) with significantly reduced activity at the wild-
The Uses of CO-1686
CO 1686 is seen as an irreversible epidermal growth factor receptor (EFGR1) kinase inhibitor.
References
[1] walter a o, tjin r, haringsma h, et al. co-1686, an orally available, mutant-selective inhibitor of the epidermal growth factor receptor (egfr), causes tumor shrinkage in non-small cell lung cancer (nsclc) with t790m resistance mutations. mol cancer ther, 2011, 10(11 suppl).
[2] walter a o, sjin r t t, haringsma h j. discovery of a mutant-selective covalent inhibitor of egfr that overcomes t790m-mediated resistance in nsclc.
Properties of CO-1686
Melting point: | 202 - 205°C (dec.) |
Density | 1.372±0.06 g/cm3(Predicted) |
storage temp. | Amber Vial, -20°C Freezer, Under inert atmosphere |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 13.23±0.70(Predicted) |
color | Off-White |
CAS DataBase Reference | 1374640-70-6 |
Safety information for CO-1686
Computed Descriptors for CO-1686
New Products
Tubulysin H Tubulysin B Tubulysin E 2,2-diethoxyethanethioamide 4-FLUOROPIPERIDINE 4,4-DIFLUOROCYCLOHEXANAMINE 3-FLUOROPYRROLIDINE HYDROCHLORIDE 1-Boc-5-broMo-1H-pyrazolo[3,4-b]pyridine 4,4-DIFLUOROCYCLOHEXYLAMINE HYDROCHLORIDE 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE (2,3-Dihydro- benzofuran-5-yl)- ethanol 1-(2,3-Dihydro- benzofuran-5-yl) -ethanone (+/-)-2, 6-Diamino-4,5,6,7 -tetrahydro Benzothiazole 5-(piperazin-1-yl) benzofuran-2- carboxamide 2-Methyl-4- nitro Benzoic acid (+/-)-6-Acetylamino-2- amino-4, 5, 6, 7-tetrahydro Benzo thiazole 7-Methoxyquinoline-4-carboxylic acid 7-Methoxyquinoline-4-carbonitrile 1H-Imidazole-4-carbonitrile (R)-methyl 2-isocyano-3-(tritylthio)propanoate (R)-methyl 2-formamido-3-(tritylthio)propanoate Sertraline 2,3-Dichloro Tetralone Methanamine Racemate BETAMETHASONE ACETATE EP IMPURITY Sildenafil Des(methylpiperazinyl) Chlorosulfone ImpurityRelated products of tetrahydrofuran
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