Poziotinib (HM781-36B)
- CAS NO.:1092364-38-9
- Empirical Formula: C23H21Cl2FN4O3
- Molecular Weight: 491.34
- MDL number: MFCD28044290
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-09-10 19:09:04
What is Poziotinib (HM781-36B)?
Description
Poziotinib is a TKI that covalently and irreversibly inhibits EGFR and HER2, and is unique because of its small terminal group and flexible quinazoline core. Its small size and flexibility allow it to evade the steric hindrance which affects other EGFR TKIs [138].
The Uses of Poziotinib (HM781-36B)
Poziotinib can be used to inhibit the growth of cancer cells.
Properties of Poziotinib (HM781-36B)
Melting point: | 187 - 190° C |
Boiling point: | 629.7±55.0 °C(Predicted) |
Density | 1.409±0.06 g/cm3(Predicted) |
storage temp. | -20°C Freezer, Under inert atmosphere |
solubility | Chloroform (Slightly), DMSO (Slightly, Sonicated) |
form | Solid |
pka | 5.35±0.30(Predicted) |
color | White to Pale Beige |
CAS DataBase Reference | 1092364-38-9 |
Safety information for Poziotinib (HM781-36B)
Computed Descriptors for Poziotinib (HM781-36B)
New Products
Tubulysin I Tubulysin G Tubulysin M (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin D 4-(Benzyloxy)-3-bromophenylacetic Acid 4,4-DIFLUOROPIPERIDINE 1-(1,1-Difluoroethyl)-2-fluorobenzene 3-N-BOC-(S)-AMINO BUTYRONITRILE Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- 2,2-Difluoropropylamine hydrochloride 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Calcium Sodium Phosphosilicate IH Fuel shell 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Imeglimin Hydrochloride IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 4-N-Methylamino- 3-nitro benzoic acid (R)-1-Aminoindan Hydrochloride Lubiprostone Latanoprostene Bunod Magnesium Trisilicate Flame Retardant Zinc Borate 7-Methoxyquinoline-4-carboxylic acidRelated products of tetrahydrofuran
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