AVL-292
- CAS NO.:1202757-89-8
- Empirical Formula: C22H22FN5O3
- Molecular Weight: 423.44
- MDL number: MFCD25976876
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:54:57
What is AVL-292?
The Uses of AVL-292
Bruton’s tyrosine kinase (BTK) is a non-receptor tyrosine kinase involved in signal transduction pathways regulating the proliferation, activation, and differentiation of B cells. AVL-292 is an orally available, selective, and irreversible inhibitor of BTK (IC50 = 0.5 nM in vitro in B cell lymphoma cell lines) that targets and covalently binds to BTK at cysteine-481, thereby preventing its activity. AVL-292 has been shown to inhibit osteoclast function and to reduce osteoclast-stimulated proliferation of multiple myeloma cells in animal models of rheumatoid arthritis and multiple sclerosis, both of which are diseases where B cells play an important role. In clinical trials, AVL-292 has demonstrated therapeutic significance in the treatment of both B cell-related cancers (e.g., non-Hodgkin’s lymphoma and B cell chronic lymphocytic leukemia) and autoimmune diseases (e.g., rheumatoid arthritis).[Cayman Chemical]
Properties of AVL-292
Density | 1.322±0.06 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | ≥21.15 mg/mL in DMSO; insoluble in H2O; ≥4.9 mg/mL in EtOH with gentle warming and ultrasonic |
form | solid |
pka | 13.22±0.70(Predicted) |
color | White to khaki |
CAS DataBase Reference | 1202757-89-8 |
Safety information for AVL-292
Computed Descriptors for AVL-292
Related products of tetrahydrofuran
You may like
-
AVL-292 >95% CAS 1202757-89-8View Details
1202757-89-8 -
N-{3-[(5-Fluoro-2-{[4-(2-methoxyethoxy)phenyl]amino}pyrimidin-4-yl)amino]phenyl}prop-2-enamide 95% CAS 1202757-89-8View Details
1202757-89-8 -
77-92-9 99%View Details
77-92-9 -
77-92-9 99%View Details
77-92-9 -
8000-27-9 CEDAR WOOD OIL 99%View Details
8000-27-9 -
AMMONIUM DICHROMATE 7789-09-5 99%View Details
7789-09-5 -
7778-80-5 POTASSIUM SULPHATE 99%View Details
7778-80-5 -
95-54-5 99%View Details
95-54-5