AVL-292
- CAS NO.:1202757-89-8
- Empirical Formula: C22H22FN5O3
- Molecular Weight: 423.44
- MDL number: MFCD25976876
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:54:57
What is AVL-292?
The Uses of AVL-292
Bruton’s tyrosine kinase (BTK) is a non-receptor tyrosine kinase involved in signal transduction pathways regulating the proliferation, activation, and differentiation of B cells. AVL-292 is an orally available, selective, and irreversible inhibitor of BTK (IC50 = 0.5 nM in vitro in B cell lymphoma cell lines) that targets and covalently binds to BTK at cysteine-481, thereby preventing its activity. AVL-292 has been shown to inhibit osteoclast function and to reduce osteoclast-stimulated proliferation of multiple myeloma cells in animal models of rheumatoid arthritis and multiple sclerosis, both of which are diseases where B cells play an important role. In clinical trials, AVL-292 has demonstrated therapeutic significance in the treatment of both B cell-related cancers (e.g., non-Hodgkin’s lymphoma and B cell chronic lymphocytic leukemia) and autoimmune diseases (e.g., rheumatoid arthritis).[Cayman Chemical]
Properties of AVL-292
Density | 1.322±0.06 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | ≥21.15 mg/mL in DMSO; insoluble in H2O; ≥4.9 mg/mL in EtOH with gentle warming and ultrasonic |
form | solid |
pka | 13.22±0.70(Predicted) |
color | White to khaki |
CAS DataBase Reference | 1202757-89-8 |
Safety information for AVL-292
Computed Descriptors for AVL-292
New Products
(R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin I CYCLOBUTYLAMINE HYDROCHLORIDE 4,4-DIFLUOROCYCLOHEXANAMINE Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 3-Aminocyclobutanone hydrochloride 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Calcium Sodium Phosphosilicate IH Imeglimin Hydrochloride IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol (R)-1-Aminoindan Hydrochloride 5-Piperazin-1-yl- benzofuran-2- carboxylic acid ethyl ester. HCl Lubiprostone Magnesium Trisilicate Latanoprostene Bunod Flame Retardant Zinc Borate 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carboxylic acid 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
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