BML-275
- CAS NO.：1219168-18-9
- Empirical Formula: C24H27Cl2N5O
- Molecular Weight: 472.41008
- MDL number: MFCD11112197
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is BML-275?
Description
Dorsomorphin (hydrochloride) is a potent, reversible inhibitor of AMP kinase (AMPK; Ki = 109 nM) that does not exhibit significant activity on structurally related kinases, including ZAPK, SYK, PKCθ, PKA, and JAK3. Dorsomorphin can also dose-dependently inhibit the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK6). Independent of AMPK inhibition, dorsomorphin, at 10 μM, has additionally been shown to downregulate the Akt/mTOR pathway to induce autophagy in U251 human glioma cells.
The Uses of BML-275
Dorsomorphin is an AMP-activated kinase (AMPK) inhibitor. Dorsomorphin selectively inhibits the bone morphogenetic protein (BMP) type I receptors ALK2, ALK3 and ALK6 and thus blocks BMP-mediated SMAD1/5/8 phosphorylation, target gene transcription and osteogenic differentiation. Dorsomorphin has shown to increase cisplatin-induced apoptosis, which was associated with hyper-induction of the tumor suppressor p53.
What are the applications of Application
Dorsomorphin dihydrochloride is a potent, selective, reversible AMP-kinase inhibitor and BMP type I receptor inhibitor that can induce autophagy.
storage
Room temperature (desiccate)
Properties of BML-275
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | insoluble in EtOH; insoluble in H2O; ≥11.34 mg/mL in 0.9% NS ; ≥39.93 mg/mL in DMSO:H2O=2:1 ; ≥5.91 mg/mL in DMSO |
| form | Light yellow powder solid. |
| color | Yellow |
| Stability: | Hygroscopic |
Safety information for BML-275
Computed Descriptors for BML-275
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Fosfomycin EP impurity D Rimegepant Impurity 3 Ivermectin EP Impurity B Tubulysin A Tubulysin I Tubulysin M 2,2-diethoxyethanethioamide 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Imeglimin Hydrochloride IH Fuel shell 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Calcium Sodium Phosphosilicate IH 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-(3,5-Di-tert-butylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 3-Morpholino-1-[4-(2-oxo-1-piperidyl)phenyl]-5,6-dihydropyridin-2(1H)-one Methyl 4-amino-3-(piperidin-1-yl)benzoate 2-Chloro-3-(chloromethyl)pyridine 1-(4-Chlorophenyl)piperidin-2-one 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione (4R,12aR)-7-Methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1`,2`;4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid 2-chloro-N-(biphenyl-2-yl) nicotinamide 4-bromo-2,5-difluoro benzoic acidRelated products of tetrahydrofuran
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