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HomeProduct name listGlucagon Receptor Antagonist I

Glucagon Receptor Antagonist I

Glucagon Receptor Antagonist I Structural

What is Glucagon Receptor Antagonist I?

Description

Glucagon receptor antagonist I is a competitive antagonist of the glucagon receptor (GCGR; IC50 = 181 nM). It blocks glucagon-induced glycogenolysis in primary human hepatocytes and isolated liver. Glucagon receptor antagonist I, at 50 mg/kg, reduces the increase in glucose levels observed after intraperitoneal administration of glucagon in humanized mice. Glucagon receptor antagonist inactive control does not prevent glucagon-mediated actions.

What are the applications of Application

Glucagon Receptor Antagonist I is a potent and selective cell-permeable glucagon receptor antagonist

Properties of Glucagon Receptor Antagonist I

Boiling point: 517.8±50.0 °C(Predicted)
Density  1.07±0.1 g/cm3(Predicted)
storage temp.  Store at -20°C
solubility  DMSO: soluble
form  White crystalline solid.
pka 13.46±0.40(Predicted)

Safety information for Glucagon Receptor Antagonist I

Computed Descriptors for Glucagon Receptor Antagonist I

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