Glucagon Receptor Antagonist I
- CAS NO.：438618-32-7
- Empirical Formula: C20H30N2OS
- Molecular Weight: 346.53
- MDL number: MFCD01920208
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-21 10:59:17
What is Glucagon Receptor Antagonist I?
Description
Glucagon receptor antagonist I is a competitive antagonist of the glucagon receptor (GCGR; IC50 = 181 nM). It blocks glucagon-induced glycogenolysis in primary human hepatocytes and isolated liver. Glucagon receptor antagonist I, at 50 mg/kg, reduces the increase in glucose levels observed after intraperitoneal administration of glucagon in humanized mice. Glucagon receptor antagonist inactive control does not prevent glucagon-mediated actions.
What are the applications of Application
Glucagon Receptor Antagonist I is a potent and selective cell-permeable glucagon receptor antagonist
Properties of Glucagon Receptor Antagonist I
| Boiling point: | 517.8±50.0 °C(Predicted) |
| Density | 1.07±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: soluble |
| form | White crystalline solid. |
| pka | 13.46±0.40(Predicted) |
Safety information for Glucagon Receptor Antagonist I
Computed Descriptors for Glucagon Receptor Antagonist I
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