A 769662
- CAS NO.:844499-71-4
- Empirical Formula: C20H12N2O3S
- Molecular Weight: 360.39
- MDL number: MFCD11977269
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
![A 769662 Structural](https://img.chemicalbook.in/CAS/GIF/844499-71-4.gif)
What is A 769662?
Description
A-
The Uses of A 769662
A 769662 is an AMP-activated protein kinase (AMPK) activiator. A 769662 selectively activates cardiac AMPK heterotrimeric complexes contg. α2/β1-subunits.
What are the applications of Application
A-769662 is an AMPK activator which induces PI3-kinase-dependent glucose uptake and inhibits AMPK dephosphorylation.
definition
ChEBI: 4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile is a member of biphenyls.
Biological Activity
Potent, reversible AMP-activated protein kinase (AMPK) activator (EC 50 = 0.8 μ M) that displays selectivity towards β 1 subunit-containing heterotrimers. Inhibits fatty acid synthesis (IC 50 = 3.2 μ M) and decreases plasma glucose and triglyceride levels in vivo .
storage
+4°C
References
1) Scott et al. (2008), Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes; Cell Biol., 15 1220 2) Cool et al. (2006), Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome; Cell Metab., 3 403 3) Zhou et al. (2009), Inhibitory effects of A-769662, a novel activator of AMP-activated protein kinase on 3T3-L1 adipogenesis; Biol. Pharm. Bull., 32?993 4) Vazquez-Martin et al. (2012) Activation of AMP-activated protein kinase (AMPK) provides a metabolic barrier to reprogramming somatic cells into stem cells; Cell Cycle, 11 974 5) Ducommun et al. (2014) Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662; Am. J. Physiol. Endocrinol. Metab., 306 E688
Properties of A 769662
Melting point: | 263 - 266oC |
Boiling point: | 630.1±55.0 °C(Predicted) |
Density | 1.56 |
Flash point: | 334.9℃ |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 5 mg/ml), |
form | solid |
pka | 4.50±1.00(Predicted) |
color | Beige |
Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
Safety information for A 769662
Computed Descriptors for A 769662
New Products
3-Pyridineacrylic acid 3-Bromo-4-fluorophenol N-Boc-Ethylenediamine cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate 4-Aminotetrahydropyran hydrochloride 4,5-Dibromopyridazin-3-one N-Benzyl-3-hydroxypiperidine 2-Methyl-4-nitrobenzoic acid 2-(4-bromophenyl)-2-methylpropanoic acid 4-Acetyl-2-methylbenzoicacid Acetyl-meldrum's acid Ethyl-4-Pyrazole carboxylate 2,4-Dichloro-5-Methylpyridine 2-Amino-6-Chloro-3-Nitropyridine 2-Chloro-4-Nitropyridine-N-Oxide 3-Amino-5-Chloropyridine 2-Fluoroisonicotinic acid 2-Hydroxy-5-Methylpyridine METHYL-4-(BUTYRYLAMINO)3-METHYL-5-NITROBENZOATE TRANS-CYCLOBUTANE-1,2- DICARBOXYLIC ACID 5-Nitro indazole R-(-)-5-(2-AMINO-PROPYL)-2-METHOXY-BENZENESULFONAMIDE 1,3-cyclohexanedione 4-AminophenaethylalcholRelated products of tetrahydrofuran
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