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HomeProduct name listAcetrizoic acid

Acetrizoic acid

  • CAS NO.:85-36-9
  • Empirical Formula: C9H6I3NO3
  • Molecular Weight: 556.86
  • MDL number: MFCD00016495
  • EINECS: 201-600-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 20:33:22
Acetrizoic acid Structural

What is Acetrizoic acid?

Chemical properties

Acetrizoic acid is an ionic monomeric contrast medium. It was first synthesized by Wallingford in 1953 and it was filled in the FDA by the Johnson & Johnson subsidiary, Cilag Chemie AG, on February 8th, 1978.Acetrizoic acid presents, in the FDA records, a category of drug substance with an inactive status.

The Uses of Acetrizoic acid

Radiopaque agent: Acetrizoic acid (trade names Gastrografina, Urografina in Portugal) is a palatable lemon-flavored water-soluble iodinated radiopaque X-ray contrast medium for oral or rectal administration only. Acetrizoic acid is indicated for radiographic examination of segments of the gastrointestinal tract (esophagus, stomach, proximal small intestine, and colon). The preparation is particularly indicated when a more viscous agent such as barium sulfate, which is not water-soluble, is not feasible or is potentially dangerous. Administration of hypertonic Gastrografin solutions may lead to hypovolemia and hypotension due to fluid loss from the intestine.

Indications

Acetrizoic acid indication was to be used as a contrast agent for X-ray. Some information indicates its nephrotropic property as one of the characteristics for the utilization of acetrizoic acid.The X-ray imaging depends on the difference in tissue density which is provided by an X-ray attenuation between the area of interest and the surrounding tissue. The use of contrast agents will provoke a contrast enhancement or opacification and it will improve the differentiation of pathological processes from normal tissue.

Definition

ChEBI: Acetrizoic acid is an aminobenzoic acid.

brand name

Salpix (Ortho-McNeil).

Safety Profile

Mildly toxic by ingestion andintravenous routes. When heated to decomposition it emitstoxic fumes of I- and NOx.

Properties of Acetrizoic acid

Melting point: 280-280.5 °C (decomp)
Boiling point: 547.1±50.0 °C(Predicted)
Density  2.5688 (estimate)
storage temp.  2-8°C(protect from light)
solubility  It is soluble in alcohol, slightly soluble in ether and water, very slightly soluble in chloroform and practically insoluble in benzene.
form  powder to crystal
pka 1.13±0.10(Predicted)
color  White power
Water Solubility  1.28g/L(25 ºC)
CAS DataBase Reference 85-36-9(CAS DataBase Reference)
NIST Chemistry Reference 3-Acetamido-2,4,6-triiodobenzoic acid(85-36-9)

Safety information for Acetrizoic acid

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for Acetrizoic acid

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