10E,12Z-octadecadienoic acid

Synonym(s):(10E,12Z)-10,12-Octadecadienoic acid;10E,Z12-CLA;Linoleic acid (10-trans, 12-cis)

CAS NO.：2420-56-6
Empirical Formula: C18H32O2
Molecular Weight: 280.45
MDL number: MFCD02259040
EINECS: 607-342-5
SAFETY DATA SHEET (SDS)
Update Date: 2024-09-09 19:09:56

What is 10E,12Z-octadecadienoic acid?

Description

Conjugated linoleic acid (CLA) refers to a family of 8 geometric isomers of linoleic acid in which the two double bonds are contiguous. (The predominant form of linoleic acid in nature, 18:ω6, has double bonds at 9 and 12, interrupted by a methylene carbon.) CLA is found in both meat and dairy products, but it is not found to any significant degree in plants. The predominant isomer of CLA in animal tissue is 9Z,11E; smaller amounts of 10E,12Z also occur. Various antioxidant and antitumor activities have been attributed to CLA or its downstream metabolites. Reported health benefits of dietary supplementation with CLA have been attributed variously to competitive inhibition of Δ⁶-desaturase and/or PPARγ activation. [Matreya, LLC. Catalog No. 1249]

The Uses of 10E,12Z-octadecadienoic acid

10-trans,12-cis-Linoleic Acid?is an isomer of Linoleic Acid (L467495). Linoleic Acid is a dietary unsaturated fatty acid, which increases the expression of adhesion molecules and attenuates Endothelial cell function. Linoleic Acid is anti-inflammatory, acne reductive, and moisture retentive when applied topically on the skin. It is popular in the beauty products industry because of its beneficial properties on the skin.

What are the applications of Application

Conjugated Linoleic Acid (10E,12Z) is a potential antioxidant

Definition

ChEBI: (10E,12Z)-octadecadienoic acid is an octadeca-10,12-dienoic acid having (10E,12Z)-configuration. It is a conjugate acid of a (10E,12Z)-octadecadienoate.

Properties of 10E,12Z-octadecadienoic acid

Boiling point:	377.7±11.0 °C(Predicted)
Density	0.911±0.06 g/cm3(Predicted)
Flash point:	14℃
storage temp.	−20°C
solubility	Chloroform (Slightly), Dichloromethane (Slightly), DMSO, Methanol (Slightly)
form	Oil
pka	4.78±0.10(Predicted)
color	Colourless
Stability:	Light Sensitive

Safety information for 10E,12Z-octadecadienoic acid

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H225:Flammable liquids H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P370+P378:In case of fire: Use … for extinction. P403+P235:Store in a well-ventilated place. Keep cool.