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HomeProduct name listCholine Fenofibrate

Choline Fenofibrate

Choline Fenofibrate Structural

What is Choline Fenofibrate?

Description

Choline fenofibrate, a salt formulation of fenofibric acid, is a lipid regulating agent available as delayed release capsules for oral administration. It is indicated in combination with a statin to reduce TG and increase high-density lipoprotein cholesterol (HDL-C) in patients with mixed dyslipidemia and coronary heart disease (CHD) or a CHD-risk equivalent who are optimal for statin therapy to achieve their lowdensity lipoprotein cholesterol (LDL-C) goal. In addition, choline fenofibrate is indicated as monotherapy in patients with severe hypertriglyceridemia to reduce TG, and in patients with primary hyperlipidemia or mixed dyslipidemia to reduce elevated LDL-C, total cholesterol, TG, apolipoprotein B, and to increase HDL-C. Fenofibric acid is also the active metabolite of fenofibrate (Tricor), which has been previously marketed for the treatment of hypercholesterolemia and hypertriglyceridemia. The primary mode of action of fenofibric acid is through the activation of the nuclear transcription factor PPARa, predominantly expressed in tissues that metabolize fatty acids, such as the liver, kidney, heart, and muscle.
On activation by binding of the fibrate, PPARa binds as heterodimers with retinoid X receptor (RXR), which subsequently recognizes and binds to specific PPARa-response elements leading to modulation of expression of the target genes. In particular, the activity of lipoprotein lipase is increased and synthesis of apoprotein C-III is decreased, which together enhance the clearance of circulating TG-rich lipoproteins. The resulting fall in TG produces an alteration in the size and composition of LDL from small dense particles to large buoyant particles. These larger particles have a greater affinity for cholesterol receptors and are catabolized rapidly. Choline fenofibriate acid is contraindicated in patients with severe renal impairment.

Chemical properties

White Solid

Originator

Abbott (United States)

The Uses of Choline Fenofibrate

A new formulation of fenofibric acid, ABT-335,

The Uses of Choline Fenofibrate

A new formulation of fenofibric acid, ABT-335, co-administered with statins.

What are the applications of Application

Choline Fenofibrate is a choline salt of fenofibric acid

brand name

TriLipix

Side Effects

The most common adverse reactions observed with the use of fenofibric acid alone or in combination with a statin are headache, back pain, nasopharyngitis, nausea, myalgia, diarrhea, and upper respiratory tract infection.

Synthesis

Choline To Market, To Market 2008 enofibrate is chemically derived from p-anisole in four steps through Friedel Crafts acylation with p-chlorobenzoyl chloride to the corresponding benzophenone derivative, followed by methyl ether cleavage with hydrogen bromide, alkylation of the phenolic hydroxyl group with 2-bromo-2-methylpropanoic acid using sodium hydroxide, and finally salt formation with choline.

Properties of Choline Fenofibrate

Melting point: 210-212°C
storage temp.  Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility  Methanol (Slightly), Water (Slightly)
form  Solid
color  White to Off-White
Stability: Hygroscopic

Safety information for Choline Fenofibrate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H332:Acute toxicity,inhalation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Choline Fenofibrate

Abamectin manufacturer

Lupin Ltd

1Y
Phone:+91-8019896181
Whatsapp: +91 8019896181
product: 856676-23-8 Choline fenofibrate 99%
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Alembic Pharmaceuticals Limited

1Y
Phone:+912652280550
product: 856676-23-8 98%
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Om Pharmaceutical Industries

1Y
Phone:+91-9822376539
Whatsapp: +91-9822376539
product: Choline fenofibrate 99%
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Harman Finochem Ltd

1Y
Phone:+91-2226528080
product: Choline fenofibrate 856676-23-8 98%
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Ralington Pharma

1Y
Phone:+91-9687771722
Whatsapp: +91- 9687771722
product: 856676-23-8 Choline fenofibrate 98%
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Ami Lifesciences Pvt Ltd

1Y
Phone:+91-9426998100
Whatsapp: +91-9426998100
product: 856676-23-8 99%
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Omshri Labs Pvt Ltd

1Y
Phone:+91-7977270534
Whatsapp: +91-7977270534
product: Choline fenofibrate 856676-23-8 99%
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DM Pharma

Tamil Nadu
product: Choline fenofibrate
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