Trimesic acid

Synonym(s):BTC;TMA;Trimesic acid;H3BTC;1,3,5-Benzenetricarboxylic acid

CAS NO.：554-95-0
Empirical Formula: C9H6O6
Molecular Weight: 210.14
MDL number: MFCD00002517
EINECS: 209-077-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 14:15:30

What is Trimesic acid?

Chemical properties

off-white powder

The Uses of Trimesic acid

Trimesic acid is mainly used in the industry of poxy curing agent ,Adhesives and coating material ,Engineering plastic ,Synthetic fiber ,Cross-linking agent for alkyd resin ,Plasticizer ,Pharmaceutical intermediates, Desalination membrane etc.

The Uses of Trimesic acid

Trimesinic Acid is used for multifunctional therapeutics. It shows inhibitory activity against Torpedo Californica acetylcholinesterase and prevented amyloid-β peptide aggregate formation.

Definition

ChEBI: Trimesic acid is a tricarboxylic acid that consists of benzene substituted by carboxy groups at positions 1, 3 and 5. It is a tricarboxylic acid and a member of benzoic acids. It is a conjugate acid of a benzene-1,3,5-tricarboxylate(1-).

What are the applications of Application

Trimesic acid is a planar benzoic acid with antiviral and chemical transport properties

General Description

Trimesic acid (TMA), also known as 1,3,5-benzenetricarboxylic acid, has a self-organized 2D molecular network structure formed by intermolecular hydrogen bonds between the carboxylic acid residues in bulk crystals. TMA can be used in the synthesis of metal-organic frameworks (MOFs), which can be used as organic linkers potentially utilized in sensors.

Flammability and Explosibility

Not classified

Synthesis

Trimesic acid can be produced by Friedel – Crafts methylation of toluene or xylene with chloromethane in the presence of aluminum chloride.It is also formed by liquid-phase disproportionation of xylene in the presence of aluminum chloride.These reactions can be carried out in the gas phase at high temperature on aluminum silicate catalysts.

Purification Methods

Crystallise the acid from water. The trimethyl ester has m 144o (from MeOH or MeOH/H2O). [Beilstein 9 H 978, 9 IV 3747.]

Properties of Trimesic acid

Melting point:	>300 °C(lit.)
Boiling point:	309.65°C (rough estimate)
Density	1.4844 (rough estimate)
vapor pressure	0Pa at 20℃
refractive index	1.6000 (estimate)
Flash point:	328°C
storage temp.	Store below +30°C.
solubility	26.3g/l
form	Powder
pka	pK1: 2.12;pK2: 4.10;pK3: 5.18 (25°C)
color	white
Water Solubility	Soluble in water, ethanol and methanol.
BRN	2053080
Stability:	Stable, but may be light sensitive.
CAS DataBase Reference	554-95-0(CAS DataBase Reference)
NIST Chemistry Reference	1,3,5-Benzenetricarboxylic acid(554-95-0)
EPA Substance Registry System	1,3,5-Benzenetricarboxylic acid (554-95-0)

Safety information for Trimesic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.