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HomeProduct name listTestosterone phenylpropionate

Testosterone phenylpropionate

Synonym(s):4-Androsten-17β-ol-3-one 17-phenylpropionate;Testosterone hydrocinnamate

  • CAS NO.:1255-49-8
  • Empirical Formula: C28H36O3
  • Molecular Weight: 420.58
  • MDL number: MFCD00056484
  • EINECS: 215-014-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 11:59:05
Testosterone phenylpropionate Structural

What is Testosterone phenylpropionate?

Description

Testosterone phenylpropionate (BAN; TPP) (brand name Testolent), or testosterone phenpropionate, also known as testosterone hydrocinnamate, is a synthetic anabolic-androgenic steroid (AAS) and an androgen ester – specifically, the C17β phenylpropionate ester of testosterone – which was formerly marketed in Romania. It was first synthesized in 1951 and was first described in the literature by 1953. The medication was an ingredient of several isolated AAS commercial products, but was never widely used. Testosterone phenylpropionate was also notably a component of Sustanon and Omnadren, as well as of Estandron Prolongatum, Lynandron Prolongatum, and Mixogen. TPP was previously available in Great Britain.

The Uses of Testosterone phenylpropionate

Testosterone 17-Phenylpropionate, is one of the 17b-fatty acid esters of testosterone, that is increasingly misused by athletes in an attempt to improve sports performance, and thus can be used in doping control. It can also be used as a therapy in glucocorticoid-treated patients to increase the circulating testosterone concentration.

Definition

ChEBI: Testosterone phenylpropionate is a steroid ester.

Biological Functions

Testosterone phenylpropionate is a synthetic anabolic-androgenic steroid (AAS) and an androgen ester. It was first reported in the scientific literature in 1955 and was an ingredient of several isolated AAS commercial products, but was never widely used. Testosterone phenylpropionate was also notably a component of Sustanon and Omnadren.

Synthesis

Synthesis_1255-49-8In a 100 ml reaction flask, 0.397 g (3 mmol) of cinnamaldehyde was added.0.411g (1.5mmol) Nandrolone, 0.06g (0.3mmol) [Bmim][OAc] catalyst, 10ml 1,4-dioxane, heated to 120 ?? C and then reacted for 2h, after the reaction was completed, cooled to room temperature, added 30 ml of water and 20 ml of ethyl acetate were extracted, and the phases were allowed to stand. The organic phase was concentrated and crystallized to obtain the target product. The yield was 64%.

Properties of Testosterone phenylpropionate

Melting point: 116.5 °C
Boiling point: 497.74°C (rough estimate)
Density  1.0043 (rough estimate)
refractive index  1.5460 (estimate)
solubility  DMF: 25 mg/mL; DMSO: 5 mg/mL; Ethanol: 15 mg/mL; Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/mL
form  neat
Water Solubility  2.25mg/L(25 ºC)
CAS DataBase Reference 1255-49-8(CAS DataBase Reference)

Safety information for Testosterone phenylpropionate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
ghs
Environment
GHS09
GHS Hazard Statements H302:Acute toxicity,oral
H351:Carcinogenicity
H361:Reproductive toxicity
H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P201:Obtain special instructions before use.
P273:Avoid release to the environment.
P308+P313:IF exposed or concerned: Get medical advice/attention.

Computed Descriptors for Testosterone phenylpropionate

InChIKey HHSXYDOROIURIP-FEZCWRLCSA-N
SMILES [C@@]12(CC[C@]3(C)[C@H](CC[C@@]3([H])[C@@]1(CCC1=CC(=O)CC[C@]21C)[H])OC(=O)CCC1C=CC=CC=1)[H] |&1:0,3,5,8,10,19,r|

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