Vonoprazan fumarate
- CAS NO.：1260141-27-2
- Empirical Formula: C21H20FN3O6S
- Molecular Weight: 461.4634032
- MDL number: MFCD18633280
- EINECS: 250-635-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-24 17:21:45
What is Vonoprazan fumarate?
Description
Vonoprazan fumarate (Takecab®), discovered and developed by Takeda and Otsuka, was approved by the PMDA of Japan in December 2014, and is indicated for the treatment of gastric ulcer, duodenal ulcer and reflux esophagitis. Vonoprazan fumarate has a novel mechanism of action called potassium-competitive acid blockers, which competitively inhibit the binding of potassium ions to H+, K+-ATPase (also known as the proton pump) in the final step of gastric acid secretion in gastric parietal cells. Vonoprazan does not inhibit Na+, K+-ATPase activity even at concentrations 500 times higher than that of their IC50 values against gastric H+, K+-ATPase activity. Furthermore, the drug is unaffected by the gastric secretory state, unlike PPIs.
The Uses of Vonoprazan fumarate
Vonoprazan Fumarate is a novel potassium-?competitive acid blocker for the treatment of acid-?related diseases.
Properties of Vonoprazan fumarate
| solubility | insoluble in H2O; insoluble in EtOH; ≥18.9 mg/mL in DMSO |
| form | solid |
Safety information for Vonoprazan fumarate
Computed Descriptors for Vonoprazan fumarate
| InChIKey | ROGSHYHKHPCCJW-WLHGVMLRSA-N |
| SMILES | N1(S(C2=CC=CN=C2)(=O)=O)C(C2=CC=CC=C2F)=CC(CNC)=C1.C(O)(=O)/C=C/C(O)=O |
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