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1260141-27-2

1260141-27-2 structural image
Product Name: Vonoprazan fumarate
Formula: C21H20FN3O6S
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COMPUTED DESCRIPTORS

Molecular Weight 461.5 g/mol
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 9
Rotatable Bond Count 7
Exact Mass 461.10568470 g/mol
Monoisotopic Mass 461.10568470 g/mol
Topological Polar Surface Area 147 Ų
Heavy Atom Count 32
Formal Charge 0
Complexity 629
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 1
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 2
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Vonoprazan Fumarate is the fumarate salt form of vonoprazan, a pyrrole derivative and reversible potassium-competitive acid blocker (P-CAB), with potential antacid activity. Upon administration, vonoprazan specifically and competitively binds to the gastric hydrogen-potassium ATPase (H+/K+ ATPase) proton pump at or, more likely, near its potassium ion (K+) binding site and sterically inhibits K+ binding. This blocks the activation of the H+/K+ ATPase by K+, inhibits the proton pump and prevents gastric acid secretion, thereby lowering gastric acid levels.

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