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HomeProduct name list(R)-3-Hydroxypyrrolidine

(R)-3-Hydroxypyrrolidine

Synonym(s):(R)-3-Hydroxypyrrolidine

  • CAS NO.:2799-21-5
  • Empirical Formula: C4H9NO
  • Molecular Weight: 87.12
  • MDL number: MFCD00145220
  • EINECS: 628-839-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-04 20:04:50
(R)-3-Hydroxypyrrolidine Structural

What is (R)-3-Hydroxypyrrolidine?

Chemical properties

clear yellow to orange-brown viscous liquid

The Uses of (R)-3-Hydroxypyrrolidine

(R)-Pyrrolidin-3-ol is used in preparation of allosteric BCR-ABL bifunctional proteolysis targeting chimera compounds.

What are the applications of Application

(R)-3-Pyrrolidinol is a ligand in the enantioselective addition of diethylzinc to aromatic aldehydes

Purification Methods

The (±)-isomer is purified by repeated distillation ( b 102-104o/12mm, 108-110o/18mm), and the (±)-picrate crystallises from EtOH with m 140-141o. The R(+)-enantiomer has b 70o/0.6mm and [] D +5.6o (c 3.63, MeOH). Its hydrochloride has a negative rotation and its dimethiodide has m 230o and [] 24 -8.02o. [Suyama & Kanno Yakugaku Zasshi (J Pharm Soc Japan) 85 531 1965, Uno et al. J Heterocycl Chem 24 1025 1987, Flanagan & Joullie Heterocycles 26 2247 1987, Beilstein 21 III/IV 44.]

Properties of (R)-3-Hydroxypyrrolidine

Melting point: 15°C
Boiling point: 215-216 °C (lit.)
alpha  6.5 º (c=3.5% in MeOH)
Density  1.078 g/mL at 20 °C (lit.)
refractive index  n20/D 1.488(lit.)
Flash point: >230 °F
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
form  Viscous Liquid
pka 14.91±0.20(Predicted)
Specific Gravity 1.048
color  Clear yellow to orange-brown
optical activity [α]20/D +6.5°, c = 3.5 in methanol
Water Solubility  Soluble in water and methanol.
Sensitive  Air Sensitive & Hygroscopic
BRN  5376132
CAS DataBase Reference 2799-21-5(CAS DataBase Reference)

Safety information for (R)-3-Hydroxypyrrolidine

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P321:Specific treatment (see … on this label).
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for (R)-3-Hydroxypyrrolidine

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