(R)-3-Hydroxypyrrolidine

Synonym(s):(R)-3-Hydroxypyrrolidine

CAS NO.：2799-21-5
Empirical Formula: C4H9NO
Molecular Weight: 87.12
MDL number: MFCD00145220
EINECS: 628-839-3
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-04 20:04:50

What is (R)-3-Hydroxypyrrolidine?

Chemical properties

clear yellow to orange-brown viscous liquid

The Uses of (R)-3-Hydroxypyrrolidine

(R)-Pyrrolidin-3-ol is used in preparation of allosteric BCR-ABL bifunctional proteolysis targeting chimera compounds.

What are the applications of Application

(R)-3-Pyrrolidinol is a ligand in the enantioselective addition of diethylzinc to aromatic aldehydes

Purification Methods

The (±)-isomer is purified by repeated distillation ( b 102-104o/12mm, 108-110o/18mm), and the (±)-picrate crystallises from EtOH with m 140-141o. The R(+)-enantiomer has b 70o/0.6mm and [] D +5.6o (c 3.63, MeOH). Its hydrochloride has a negative rotation and its dimethiodide has m 230o and [] 24 -8.02o. [Suyama & Kanno Yakugaku Zasshi (J Pharm Soc Japan) 85 531 1965, Uno et al. J Heterocycl Chem 24 1025 1987, Flanagan & Joullie Heterocycles 26 2247 1987, Beilstein 21 III/IV 44.]

Properties of (R)-3-Hydroxypyrrolidine

Melting point:	15°C
Boiling point:	215-216 °C (lit.)
alpha	6.5 º (c=3.5% in MeOH)
Density	1.078 g/mL at 20 °C (lit.)
refractive index	n20/D 1.488(lit.)
Flash point:	>230 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	Viscous Liquid
pka	14.91±0.20(Predicted)
Specific Gravity	1.048
color	Clear yellow to orange-brown
optical activity	[α]20/D +6.5°, c = 3.5 in methanol
Water Solubility	Soluble in water and methanol.
Sensitive	Air Sensitive & Hygroscopic
BRN	5376132
CAS DataBase Reference	2799-21-5(CAS DataBase Reference)

Safety information for (R)-3-Hydroxypyrrolidine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see … on this label). P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.