N-Methyl-2-pyrrolidone

Description

N-Methyl-2-pyrrolidone is an aprotic solvent with a wide range of applications: petrochemical processing, surface coating, dyes and pigments, industrial and domestic cleaning compounds, and agricultural and pharmaceutical formulations. It is mainly an irritant, but has also caused several cases of contact dermatitis in a small electrotechnical company.

The Uses of N-Methyl-2-pyrrolidone

N-Methyl-2-pyrrolidone is a polar solvent that is used in organic chemistry and polymer chemistry. Large scale applications include the recovery and purification of acetylenes, olefins, and diolefins, gas purification, and aromatics extraction from feedstocks.N-Methyl-2-pyrrolidone is a versatile industrial solvent. NMP is currently approved for use only in veterinary pharmaceuticals. The determination of the disposition and metabolism of NMP in the rat will contribute toward understanding the toxicology of this exogenous chemical which man may likely be exposed to in increasing amounts.

The Uses of N-Methyl-2-pyrrolidone

N-Methyl-2-pyrrolidone (NMP) is a very strong solubilizing agent and has important applications in different fields of industry. NMP can dissolve organic and inorganic compounds equally or better than chlorofluorocarbon solvents. Therefore, NMP is used in various industrial fields as a cleaning or release agent. NMP is replacing 1,1,1-trichloroethane in metal cleaning applications due to the worldwide environmental pollution problems associated with chlorinated solvents.
NMP is a polar aprotic solvent frequently used in industrial and pharmaceutical settings. NMP is remarkably effective in maintaining dispersions of different types of nanomaterials. Given its safety profile at established doses and its competence to solubilize multiple types of drugs, NMP has become a common solvent component of in situ forming implants for long-term drug delivery. NMP acts as a co-solvent and complexing agent in different embodiments, and it has been reported to increase the solubility and permeability of multiple compounds. Transcriptional activity of bromodomain-containing proteins is compromised by NMP interaction with the binding pocket of different bromodomains, which would contribute to its anti-myeloma and immunomodulatory activity.

What are the applications of Application

1-Methyl-2-pyrrolidinone is a pyrrolidinone compound

Chemical property

N-Methyl-2-pyrrolidone (NMP) is an organic compound consisting of a 5-membered lactam. It is a colorless liquid, although impure samples can appear yellow. It is a polar aprotic solvent with similar properties to DMF, DMA, and DMSO. It is a strongly basic solvent miscible with water and other polar solvents such as alcohols, ketones, and chloroform. It has a variety of uses in the manufacture of petroleum products, polymers, pharmaceuticals, and textiles. Despite its desirable properties, its use may decline because it has been identified as a reproductive toxin.