(R)-2-Phenylpyrrolidine
- CAS NO.:56523-47-8
- Empirical Formula: C10H13N
- Molecular Weight: 147.22
- MDL number: MFCD06762513
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-27 17:58:14
What is (R)-2-Phenylpyrrolidine?
Description
(R)-2-Phenylpyrrolidine is a boronic ester that can be administered orally. It has been shown to have nootropic and memory-enhancing activities in rats, but it does not have any known effects on kinase activities, amines, factor receptors, or synthetic activity.
The Uses of (R)-2-Phenylpyrrolidine
(R)-2-Phenylpyrrolidine has also been shown to have prognostic value in cancer patients and can inhibit the growth of human cancer cells. This drug has been shown to bind to tropomyosin and growth factors with high affinity.
Definition
(R)-2-Phenylpyrrolidine is a novel class of selective pan-TRK inhibitors with efficacy in a KM12 rat tumor model. Since it was reported, this moiety has become a privileged TRK structure and was incorporated effectively in closely related scaffolds and on unrelated bicycle scaffolds. Its optimal shape complementarity to the TRK protein’s hydrophobic pocket available in the “DFG-in” conformation[1].
Origin
(R)-2-phenylpyrrolidine was first reported in 2008 by Ferrand S et al.
Properties and Applications
(R)-2-Phenylpyrrolidine is a yellow crystal,it is used as a pharmaceutical intermediate.
References
[1] Choi H, et al. (R)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors. ACS Medicinal Chemistry Letters, 2015; 14: 562–567.
Properties of (R)-2-Phenylpyrrolidine
Boiling point: | 120 °C(Press: 6 Torr) |
Density | 0.988±0.06 g/cm3(Predicted) |
storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
pka | 10.13±0.10(Predicted) |
Safety information for (R)-2-Phenylpyrrolidine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (R)-2-Phenylpyrrolidine
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