Pamoic acid
Synonym(s):1,1′-Methylene-bis(2-hydroxy-3-naphthoic acid);4,4′-Methylenebis(3-hydroxy-2-naphthoic acid);Embonic acid;Pamoic acid
- CAS NO.:130-85-8
- Empirical Formula: C23H16O6
- Molecular Weight: 388.37
- MDL number: MFCD00004079
- EINECS: 204-998-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-28 19:59:05
What is Pamoic acid?
Chemical properties
Pamoic acid is yellow to yellow-green crystalline powder
The Uses of Pamoic acid
Pamoic acid is a potent GPR35 agonist that has been found to exhibit antimicrobial activity against a variety of microorganisms. Pamoic acid is also used in the treatment of infectious diseases, such as leprosy, tuberculosis, and AIDS.
The Uses of Pamoic acid
Pamoic acid is used in preparation of repository derivatives of medicinal agents, used in pharmacology to increase the solubility of a drug in water.
Definition
ChEBI: Pamoic acid is a dicarboxylic acid. It is functionally related to a 2-naphthoic acid. It is a conjugate acid of a pamoate(2-).
General Description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Safety Profile
Poison by intraperitoneal route. An eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
Mechanism of action
Pamoic acid is able to inhibit the synthesis of peptide hormones by binding to their receptors on the cell surface. This inhibition can lead to immunosuppression (e.g., autoimmune diseases) and mitochondrial membrane depolarization.
Preparation
Pamoic acid can be prepared by the reaction of 3-hydroxy-2-naphthoic acid with formaldehyde.
Properties of Pamoic acid
Melting point: | ≥300 °C (dec.) |
Boiling point: | 434.1°C (rough estimate) |
Density | 1.2472 (rough estimate) |
refractive index | 1.4593 (estimate) |
storage temp. | Sealed in dry,Room Temperature |
solubility | Soluble in nitrobenzene, pyridine |
pka | 2.67±0.30(Predicted) |
form | Crystalline Powder |
color | Yellow to yellow-green |
Water Solubility | PRACTICALLY INSOLUBLE |
Merck | 14,7005 |
BRN | 901319 |
CAS DataBase Reference | 130-85-8(CAS DataBase Reference) |
EPA Substance Registry System | 2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy- (130-85-8) |
Safety information for Pamoic acid
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for Pamoic acid
InChIKey | WLJNZVDCPSBLRP-UHFFFAOYSA-N |
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Medicina Lyfe Care
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