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HomeProduct name listPamoic acid

Pamoic acid

Synonym(s):1,1′-Methylene-bis(2-hydroxy-3-naphthoic acid);4,4′-Methylenebis(3-hydroxy-2-naphthoic acid);Embonic acid;Pamoic acid

  • CAS NO.:130-85-8
  • Empirical Formula: C23H16O6
  • Molecular Weight: 388.37
  • MDL number: MFCD00004079
  • EINECS: 204-998-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-05-28 19:59:05
Pamoic acid Structural

What is Pamoic acid?

Chemical properties

Pamoic acid is yellow to yellow-green crystalline powder

The Uses of Pamoic acid

Pamoic acid is used in preparation of repository derivatives of medicinal agents, used in pharmacology to increase the solubility of a drug in water.

The Uses of Pamoic acid

Pamoic acid is a potent GPR35 agonist that has been found to exhibit antimicrobial activity against a variety of microorganisms. Pamoic acid is also used in the treatment of infectious diseases, such as leprosy, tuberculosis, and AIDS.

Definition

ChEBI: Pamoic acid is a dicarboxylic acid. It is functionally related to a 2-naphthoic acid. It is a conjugate acid of a pamoate(2-).

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Safety Profile

Poison by intraperitoneal route. An eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.

Mechanism of action

Pamoic acid is able to inhibit the synthesis of peptide hormones by binding to their receptors on the cell surface. This inhibition can lead to immunosuppression (e.g., autoimmune diseases) and mitochondrial membrane depolarization.

Preparation

Pamoic acid can be prepared by the reaction of 3-hydroxy-2-naphthoic acid with formaldehyde.

Properties of Pamoic acid

Melting point: ≥300 °C (dec.)
Boiling point: 434.1°C (rough estimate)
Density  1.2472 (rough estimate)
refractive index  1.4593 (estimate)
storage temp.  Sealed in dry,Room Temperature
solubility  Soluble in nitrobenzene, pyridine
pka 2.67±0.30(Predicted)
form  Crystalline Powder
color  Yellow to yellow-green
Water Solubility  PRACTICALLY INSOLUBLE
Merck  14,7005
BRN  901319
CAS DataBase Reference 130-85-8(CAS DataBase Reference)
EPA Substance Registry System 2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy- (130-85-8)

Safety information for Pamoic acid

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for Pamoic acid

InChIKey WLJNZVDCPSBLRP-UHFFFAOYSA-N

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