Methylboronic acid

Synonym(s):Methaneboronic acid

White to light yellow crystal powde

Methylboronic Acid is a methylated derivative of boronic acid, a building block towards various intermediates in suzuki coupling.

suzuki reaction

Methylboronic acid can be used as a reagent:

In the palladium-catalyzed Stille and Suzuki-Miyaura cross-couplings.
In the microwave-heated heterogeneous palladium (Pd)-catalytized reactions.
In ruthenium (Ru)-catalyzed silylation reactions
To prepare bis(aminotropone) titanium (Ti) catalysts for ethylene polymerizations.
In the enantioselective asymmetric bromoaminocyclization and bromoaminocyclization using amino-thiocarbamate catalysts.
To prepare common building blocks for pharmaceuticals and agrochemicals.
To prepare chrysin analogs by Suzuki-Miyaura coupling reactions.
To prepare casein kinase I inhibitors.
In the divergent C-H functionalizations directed by sulfonamide pharmacophores in drug discovery.
In the synthesis of unsymmetrical monosulfides from disulfides via copper-catalyzed coupling with boronic acids.
In a palladium-catalyzed coupling with enol tosylates.
For derivatizing many carbohydrates and biologically active compounds for GLC analysis.

Methylboronic acid is a reagent for derivatizing many carbohydrates and biologically active compounds

Melting point:	91-94 °C (lit.)
Boiling point:	141.7±23.0 °C(Predicted)
Density	0.965±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	DMSO, Water
form	Crystalline Powder
pka	9.97±0.43(Predicted)
color	White to off-white
Water Solubility	Soluble in water.
Sensitive	Hygroscopic
BRN	1731087
InChI	InChI=1S/CH5BO2/c1-2(3)4/h3-4H,1H3
CAS DataBase Reference	13061-96-6(CAS DataBase Reference)

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.