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HomeProduct name listLynestrenol

Lynestrenol

Synonym(s):(17α)-19-Norpregn-4-en-20-yn-17-ol

  • CAS NO.:52-76-6
  • Empirical Formula: C20H28O
  • Molecular Weight: 284.44
  • MDL number: MFCD00051135
  • EINECS: 200-151-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-07 21:39:59
Lynestrenol  Structural

What is Lynestrenol ?

Chemical properties

White or almost white, crystalline powder.

The Uses of Lynestrenol

Lynestrenol is an orally available progestogen hormone used in contraception to avoid hereditary angiodema as well as in treatment of ischemic stroke.

The Uses of Lynestrenol

Progestogen;Antioestrogen

Background

Lynestrenol is a progestin and prodrug of norethisterone.

Definition

ChEBI: Lynestrenol is a steroid. It derives from a hydride of an estrane.

brand name

Anacycline 101;Anacylin 101;Anacylin 28;Ancylin;Athilyn;Endometril;Exluton (a);Fysiognens;Fysionorm;Gestrol;Lindiol 2.5;Lyn_ratiopharm;Lyn_ratiophram_sequenz;Lyndeol;Lyndile tt;Lyndiol e.;Lyndiolett;Lynoenstrenol;Lyn-ratiopharm;Mini pregnon;Minifol;Minilyn;Neo lyndiol;Neo-lindiol;Neo-lynobol;Nonovulet;Noracyclin 22;Normophasic;Novostat;Org 485-50;Orgaluton;Orgametrol;Ovamezzo;Ovanone;Ovanon-e;Ovariostat;Ovoresta micro;Ovostat-28;Ovostat-micro;Phasicon;Physiostat;Physistat;Pregnon-28;Restovar.

World Health Organization (WHO)

Lynestrenol, a synthetic progestogen, was introduced in the early 1960s as a component in oral contraceptive preparations. In 1967, as a result of new regulations required by the United States Food and Drug Administration, lynestrenol was submitted to long-term toxicity studies and by the early 1970s it was shown to be associated with an increased incidence of mammary tumours in beagle bitches which led to its withdrawal by at least one regulatory authority. Subsequently the validity of the beagle bitch model as a predictor of carcinogenicity of steroid contraceptives has been contested by many national regulatory authorities and lynestrenol remains available in some countries for contraceptive and other purposes. (Reference: (WHODI) WHO Drug Information, 1-3, 5-7, 1984)

Safety Profile

An experimental teratogen.Experimental reproductive effects. Human reproductiveeffects by ingestion and implant routes: menstrual cyclechanges or disorders, female fertility index, other fertilitychanges and effects on females. Questionable carcinoge

Metabolism

Not Available

Properties of Lynestrenol

Melting point: 158°C
Boiling point: 366.92°C (rough estimate)
alpha  D -13° (chloroform)
Density  1.0083 (rough estimate)
refractive index  1.4500 (estimate)
storage temp.  2-8°C
solubility  Practically insoluble in water, soluble in acetone and in ethanol (96 per cent).
form  neat
pka 13.12±0.40(Predicted)
form  Solid
color  Crystals from MeOH
Merck  14,5629
CAS DataBase Reference 52-76-6
EPA Substance Registry System Lynestrenol (52-76-6)

Safety information for Lynestrenol

Signal word Warning
Pictogram(s)
ghs
Health Hazard
GHS08
GHS Hazard Statements H351:Carcinogenicity
H361:Reproductive toxicity
Precautionary Statement Codes P201:Obtain special instructions before use.
P202:Do not handle until all safety precautions have been read and understood.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313:IF exposed or concerned: Get medical advice/attention.
P405:Store locked up.
P501:Dispose of contents/container to..…

Computed Descriptors for Lynestrenol

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