Lynestrenol

Synonym(s):(17α)-19-Norpregn-4-en-20-yn-17-ol

CAS NO.：52-76-6
Empirical Formula: C20H28O
Molecular Weight: 284.44
MDL number: MFCD00051135
EINECS: 200-151-4
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 23:02:33

What is Lynestrenol ?

Chemical properties

White or almost white, crystalline powder.

The Uses of Lynestrenol

Lynestrenol is an orally available progestogen hormone used in contraception to avoid hereditary angiodema as well as in treatment of ischemic stroke.

The Uses of Lynestrenol

Progestogen;Antioestrogen

Background

Lynestrenol is a progestin and prodrug of norethisterone.

Definition

ChEBI: Lynestrenol is a steroid. It derives from a hydride of an estrane.

brand name

Anacycline 101;Anacylin 101;Anacylin 28;Ancylin;Athilyn;Endometril;Exluton (a);Fysiognens;Fysionorm;Gestrol;Lindiol 2.5;Lyn_ratiopharm;Lyn_ratiophram_sequenz;Lyndeol;Lyndile tt;Lyndiol e.;Lyndiolett;Lynoenstrenol;Lyn-ratiopharm;Mini pregnon;Minifol;Minilyn;Neo lyndiol;Neo-lindiol;Neo-lynobol;Nonovulet;Noracyclin 22;Normophasic;Novostat;Org 485-50;Orgaluton;Orgametrol;Ovamezzo;Ovanone;Ovanon-e;Ovariostat;Ovoresta micro;Ovostat-28;Ovostat-micro;Phasicon;Physiostat;Physistat;Pregnon-28;Restovar.

World Health Organization (WHO)

Lynestrenol, a synthetic progestogen, was introduced in the early 1960s as a component in oral contraceptive preparations. In 1967, as a result of new regulations required by the United States Food and Drug Administration, lynestrenol was submitted to long-term toxicity studies and by the early 1970s it was shown to be associated with an increased incidence of mammary tumours in beagle bitches which led to its withdrawal by at least one regulatory authority. Subsequently the validity of the beagle bitch model as a predictor of carcinogenicity of steroid contraceptives has been contested by many national regulatory authorities and lynestrenol remains available in some countries for contraceptive and other purposes. (Reference: (WHODI) WHO Drug Information, 1-3, 5-7, 1984)

Safety Profile

An experimental teratogen.Experimental reproductive effects. Human reproductiveeffects by ingestion and implant routes: menstrual cyclechanges or disorders, female fertility index, other fertilitychanges and effects on females. Questionable carcinoge

Metabolism

Not Available

Properties of Lynestrenol

Melting point:	158°C
Boiling point:	366.92°C (rough estimate)
alpha	D -13° (chloroform)
Density	1.0083 (rough estimate)
refractive index	1.4500 (estimate)
storage temp.	2-8°C
solubility	Practically insoluble in water, soluble in acetone and in ethanol (96 per cent).
form	neat
pka	13.12±0.40(Predicted)
form	Solid
color	Crystals from MeOH
Merck	14,5629
CAS DataBase Reference	52-76-6
EPA Substance Registry System	Lynestrenol (52-76-6)

Safety information for Lynestrenol

Signal word	Warning
Pictogram(s)	Health Hazard GHS08
GHS Hazard Statements	H351:Carcinogenicity H361:Reproductive toxicity
Precautionary Statement Codes	P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P280:Wear protective gloves/protective clothing/eye protection/face protection. P308+P313:IF exposed or concerned: Get medical advice/attention. P405:Store locked up. P501:Dispose of contents/container to..…