Lynestrenol
Synonym(s):(17α)-19-Norpregn-4-en-20-yn-17-ol
- CAS NO.:52-76-6
- Empirical Formula: C20H28O
- Molecular Weight: 284.44
- MDL number: MFCD00051135
- EINECS: 200-151-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:07:02
What is Lynestrenol ?
Chemical properties
White or almost white, crystalline powder.
The Uses of Lynestrenol
Lynestrenol is an orally available progestogen hormone used in contraception to avoid hereditary angiodema as well as in treatment of ischemic stroke.
The Uses of Lynestrenol
Progestogen;Antioestrogen
Background
Lynestrenol is a progestin and prodrug of norethisterone.
Definition
ChEBI: Lynestrenol is a steroid. It derives from a hydride of an estrane.
brand name
Anacycline 101;Anacylin 101;Anacylin 28;Ancylin;Athilyn;Endometril;Exluton (a);Fysiognens;Fysionorm;Gestrol;Lindiol 2.5;Lyn_ratiopharm;Lyn_ratiophram_sequenz;Lyndeol;Lyndile tt;Lyndiol e.;Lyndiolett;Lynoenstrenol;Lyn-ratiopharm;Mini pregnon;Minifol;Minilyn;Neo lyndiol;Neo-lindiol;Neo-lynobol;Nonovulet;Noracyclin 22;Normophasic;Novostat;Org 485-50;Orgaluton;Orgametrol;Ovamezzo;Ovanone;Ovanon-e;Ovariostat;Ovoresta micro;Ovostat-28;Ovostat-micro;Phasicon;Physiostat;Physistat;Pregnon-28;Restovar.
World Health Organization (WHO)
Lynestrenol, a synthetic progestogen, was introduced in the early 1960s as a component in oral contraceptive preparations. In 1967, as a result of new regulations required by the United States Food and Drug Administration, lynestrenol was submitted to long-term toxicity studies and by the early 1970s it was shown to be associated with an increased incidence of mammary tumours in beagle bitches which led to its withdrawal by at least one regulatory authority. Subsequently the validity of the beagle bitch model as a predictor of carcinogenicity of steroid contraceptives has been contested by many national regulatory authorities and lynestrenol remains available in some countries for contraceptive and other purposes. (Reference: (WHODI) WHO Drug Information, 1-3, 5-7, 1984)
Safety Profile
An experimental teratogen.Experimental reproductive effects. Human reproductiveeffects by ingestion and implant routes: menstrual cyclechanges or disorders, female fertility index, other fertilitychanges and effects on females. Questionable carcinoge
Metabolism
Not Available
Properties of Lynestrenol
Melting point: | 158°C |
Boiling point: | 366.92°C (rough estimate) |
alpha | D -13° (chloroform) |
Density | 1.0083 (rough estimate) |
refractive index | 1.4500 (estimate) |
storage temp. | 2-8°C |
solubility | Practically insoluble in water, soluble in acetone and in ethanol (96 per cent). |
form | neat |
pka | 13.12±0.40(Predicted) |
form | Solid |
color | Crystals from MeOH |
Merck | 14,5629 |
CAS DataBase Reference | 52-76-6 |
EPA Substance Registry System | Lynestrenol (52-76-6) |
Safety information for Lynestrenol
Signal word | Warning |
Pictogram(s) |
Health Hazard GHS08 |
GHS Hazard Statements |
H351:Carcinogenicity H361:Reproductive toxicity |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P280:Wear protective gloves/protective clothing/eye protection/face protection. P308+P313:IF exposed or concerned: Get medical advice/attention. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for Lynestrenol
Lynestrenol manufacturer
Asg Biochem Pvt. Ltd
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