Hydrocortisone acetate
Synonym(s):11β,17α,21-Trihydroxy-4-pregnene-3,20-dione 21-acetate;17-α-Hydroxycorticosterone acetate;17-Hydroxycorticosterone 21-acetate;21-Acetoxy-4-pregnene-11β,17α-diol-3,20-dione;4-Pregnene-11β,17α,21-triol-3,20-dione 21-acetate
- CAS NO.:50-03-3
- Empirical Formula: C23H32O6
- Molecular Weight: 404.5
- MDL number: MFCD00037714
- EINECS: 200-004-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-25 17:59:01
What is Hydrocortisone acetate?
Absorption
Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption.
Toxicity
Side effects include inhibition of bone formation, suppression of calcium absorption and delayed wound healing
The Uses of Hydrocortisone acetate
Hydrocortisone acetate is used to treat hemorrhoids and itching/swelling in the rectum and anus. It is used to treat certain intestinal problems (such as ulcerative colitis of the rectum and other rectal/anal inflammatory conditions).
Indications
For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.
What are the applications of Application
Hydrocortisone 21-acetate is a corticosteroid with anti-inflammatory properties
Pharmacokinetics
Hydrocortisone is the most important human glucocorticoid. It is essential for life and regulates or supports a variety of important cardiovascular, metabolic, immunologic and homeostatic functions. Topical hydrocortisone is used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses. Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects. Glucocorticoids are distinguished from mineralocorticoids and sex steroids by having different receptors, target cells, and effects. Technically, the term corticosteroid refers to both glucocorticoids and mineralocorticoids, but is often used as a synonym for glucocorticoid. Glucocorticoids suppress cell-mediated immunity. They act by inhibiting genes that code for the cytokines IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8 and TNF-alpha, the most important of which is the IL-2. Reduced cytokine production limits T cell proliferation. Glucocorticoids also suppress humoral immunity, causing B cells to express lower amounts of IL-2 and IL-2 receptors. This diminishes both B cell clonal expansion and antibody synthesis. The diminished amounts of IL-2 also leads to fewer T lymphocyte cells being activated.
Metabolism
Primarily hepatic via CYP3A4
Properties of Hydrocortisone acetate
Melting point: | 223 °C (dec.)(lit.) |
Boiling point: | 446.1°C (rough estimate) |
Density | d420 1.289 |
Flash point: | 223°C |
storage temp. | 0-6°C |
solubility | Practically insoluble in water, slightly soluble in anhydrous ethanol and in methylene chloride |
form | Solid |
color | White to Off-White |
Water Solubility | Insoluble in water. |
Safety information for Hydrocortisone acetate
Signal word | Danger |
Pictogram(s) |
Health Hazard GHS08 |
GHS Hazard Statements |
H373:Specific target organ toxicity, repeated exposure |
Precautionary Statement Codes |
P202:Do not handle until all safety precautions have been read and understood. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P308+P313:IF exposed or concerned: Get medical advice/attention. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for Hydrocortisone acetate
Abamectin manufacturer
AnalyticsStanza Inc
Horster Biotek Pvt Ltd
Maharshi Pharma Chem
Prachem Laboratories
New Products
3-N-BOC-(S)-AMINO BUTYRONITRILE 4-Piperidinopiperidine 2-Methyl-4-nitrobenzoic acid 2-(4-bromophenyl)-2-methylpropanoic acid 4-Acetyl-2-methylbenzoicacid Acetyl-meldrum's acid Ethyl-4-Pyrazole carboxylate 2,6 Di acetylpyridine 2,6-Pyridinedimethanol 5,7-Dichloro-3H-Imidazo[4,5-B]Pyridine 5-Bromo-2-Methoxy-4-Methyl-3-Nitropyridine 2-Fluoro-5-Iodopyridine 2-Fluoro-5-Methylpyridine 2-Chloro-3-Bromo-5-Amiopyridine METHYL-4-(BUTYRYLAMINO)3-METHYL-5-NITROBENZOATE TRANS-CYCLOBUTANE-1,2- DICARBOXYLIC ACID 5-Nitro indazole R-(-)-5-(2-AMINO-PROPYL)-2-METHOXY-BENZENESULFONAMIDE 1,3-cyclohexanedione 4-Aminophenaethylalchol (S)-(+)-4-BENZYL-2-OXAZOLIDINONE 3-NITRO-5-ACETYL IMINODIBENZYL 4-FLUORO PHENYL MAGNESIUM BROMIDE 1.0 M IN THF 1-HYDROXY-4-METHYL6-(2,4,4-TRI METHYL PHENYL)-2-PYRIDONE MONO ETHANOL AMINE(PIROCTONE OLAMINE)Related products of tetrahydrofuran
You may like
-
50-03-3 Reference Standards Hydrocortisone Acctate CRS -1 Vial EPCRS-H140000 98.10View Details
50-03-3 -
50-03-3 98%View Details
50-03-3 -
Hydrocortisone Acetate 99%View Details
-
Hydrocortisone acetate 50-03-3 98%View Details
50-03-3 -
Hydrocortisone acetate 99%View Details
-
50-03-3 98%View Details
50-03-3 -
50-03-3 Hydrocortisone acetate 98%View Details
50-03-3 -
Hydrocortisone acetate 50-03-3 99%View Details
50-03-3