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HomeProduct name listHydrocortisone-17-butyrate

Hydrocortisone-17-butyrate

Synonym(s):11β,17,21-Trihydroxypregn-4-ene-3,20-dione 17-butyrate;Cortisol 17-butyrate;Hydrocortisone 17-butyrate

  • CAS NO.:13609-67-1
  • Empirical Formula: C25H36O6
  • Molecular Weight: 432.56
  • MDL number: MFCD00083364
  • EINECS: 237-093-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 20:33:22
Hydrocortisone-17-butyrate Structural

What is Hydrocortisone-17-butyrate?

Absorption

Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption.

Toxicity

Side effects include inhibition of bone formation, suppression of calcium absorption and delayed wound healing

The Uses of Hydrocortisone-17-butyrate

Hydrocortisone-17-butyrate is a topical corticosteroid with anti-inflammatory properties; marker for topical corticosteroid allergy.

The Uses of Hydrocortisone-17-butyrate

antineoplastic

The Uses of Hydrocortisone-17-butyrate

Hydrocortisone Butyrate is a topical corticosteroid use to treat a variety of dermatological conditions. It acts as an antiinflammatory, antiproliferative and immunosuppresive agent.

Indications

For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.

Definition

ChEBI: Cortisol esterified with butyric acid at the 17-hydroxy group.

brand name

Locoid (Ferndale); Locoid (Yamanouchi).

Contact allergens

Hydrocortisone 17-butyrate is a C 17 ester of hydrocorti- sone. It represents the D2 group of corticosteroids, non C 16 methylated with a C 17 ester: hydrocortisone 17-butyrate, hydrocortisone 17-valerate, hydrocortisone aceponate (17-propionate and 21-acetate), methylpred- nisolone aceponate, and prednicarbate. It is sometimes hydrolyzed in vivo into hydrocortisone, giving allergic reactions to group-A-sensitized people.

Biochem/physiol Actions

Hydrocortisone 17-butyrate is a corticosteroid that acts as a dermocorticoid due to its application in dermatological therapy. It exhibits therapeutic effects against vitiligo of the face and neck.

Pharmacokinetics

Hydrocortisone is the most important human glucocorticoid. It is essential for life and regulates or supports a variety of important cardiovascular, metabolic, immunologic and homeostatic functions. Topical hydrocortisone is used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses. Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects. Glucocorticoids are distinguished from mineralocorticoids and sex steroids by having different receptors, target cells, and effects. Technically, the term corticosteroid refers to both glucocorticoids and mineralocorticoids, but is often used as a synonym for glucocorticoid. Glucocorticoids suppress cell-mediated immunity. They act by inhibiting genes that code for the cytokines IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8 and TNF-alpha, the most important of which is the IL-2. Reduced cytokine production limits T cell proliferation. Glucocorticoids also suppress humoral immunity, causing B cells to express lower amounts of IL-2 and IL-2 receptors. This diminishes both B cell clonal expansion and antibody synthesis. The diminished amounts of IL-2 also leads to fewer T lymphocyte cells being activated.

Metabolism

Primarily hepatic via CYP3A4

Properties of Hydrocortisone-17-butyrate

Melting point: 210.0 to 214.0 °C
Boiling point: 466.2°C (rough estimate)
Density  1.0914 (rough estimate)
refractive index  1.4593 (estimate)
storage temp.  Refrigerator
solubility  Chloroform (Slightly), Methanol (Slightly)
form  neat
pka 12.98±0.10(Predicted)
form  Solid
color  White to Off-White
Merck  14,4787
CAS DataBase Reference 13609-67-1(CAS DataBase Reference)

Safety information for Hydrocortisone-17-butyrate

Computed Descriptors for Hydrocortisone-17-butyrate

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