Hydrazine sulfate

Description

Hydrazine sulfate is a white or colorless, crys-talline powder; Freezing/Melting point = 254℃ (decompo-sition). HazardIdentification (based on NFPA-704 MRating System): Health 3, Flammability 1, Reactivity 1.Soluble in water.

Chemical properties

colourless crystals or white powder

Physical properties

Colorless orthorhombic crystal; density 1.378 g/cm3; melts at 254°C; sparingly soluble in cold water 1.64% at 0°C and 3.41% at 25°C; more soluble inhot water; practically insoluble in alcohol (0.04% at 25°C).

The Uses of Hydrazine sulfate

Hydrazine sulfate is used in the gravimetric estimation of nickel, cobalt and cadmium; in the refining of rare metals; as an antioxidant in soldering flux for light metals; as a reducing agent in the analysis of minerals and slags; in separating polonium from tellurium; in tests for blood; for destroying fungi and molds; in the preparation of hydrazine hydrate; press ure stabilizer in cutting oils.

The Uses of Hydrazine sulfate

In the gravimetric estimation of nickel, cobalt and cadmium; in the refining of rare metals; as antioxidant in soldering flux for light metals; as reducing agent in the analysis of minerals and slags; in separating polonium from tellurium; in tests for blood; for destroying fungi and molds; in the preparation of hydrazine hydrate.

The Uses of Hydrazine sulfate

Reagent for determination of C-terminal amino acidsHydrazine sulfate is used in analytical chemistry for the gravimetric estimation of nickel, cobalt and cadmium. It is also used in the refining of rare metals as well as in the separation of polonium from tellurium. It finds application in the synthesis of chemical intermediate and organic compounds. Further, it acts as an antioxidant in soldering flux for light metals and as a precursor to hydrazine.

What are the applications of Application

Hydrazine sulfate is a useful agent for the N-deacylation of various molecules

Preparation

Hydrazine sulfate may be synthesized from aqueous ammonia and sodium hypochlorite solution in a two-step process. In the first stage, aqueous solution of ammonia is boiled with a normal solution of sodium hypochlorite in the presence of 10% gelatin solution to yield hydrazine. In the second stage, the hydrazine solution is ice-cooled followed by slow addition of concentrated sulfuric acid (Adams, R., and B.K. Brown. 1964. In Organic Synthesis, Collective Volume I, ed. H. Gilman and A. H. Blatt, 2nd ed. pp 309-310, New York: John Wiley & Sons). The reaction steps are as follows:
2NH3 + NaOCl → NH2NH2 + H2O + NaCl
NH2NH2 + H2SO4 → NH2NH2 •H2SO4

General Description

Hydrazine sulfate salt is a potential anticachexia agent for treating cancer patients.

Hazard

A carcinogen (OSHA).

Potential Exposure

Used in analysis and refining of miner-als, rare metals, determination of arsenic in metals, as a .catalyst and an antioxidant, and in fungicides, germicides,and blood tests. Used as a catalyst for making acetatefibers.

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irri gate immediately for at least15 min, occasionally lifting upper and lower lids. Seek med-ical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, includ-ing resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medi-cal attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit. Asfirst aid for pulmonary edema, a doctor or authorized para-medic may consider administering a corticosteroid spray.Notetophysician:Treat formethemoglobinemia.Spectrophotometry may be required for precise determina-tion of levels of methemoglobin in urine. Pyridoxine(25 mg/kg) is an effective anticonvulsant for hydrazinepoisoning.

Carcinogenicity

Hydrazine and hydrazine sulfate are reasonably anticipated to be human carcinogens based on sufficient evidence of carcinogenicity from studies in experimental animals.

storage

(1) Color Code- Yellow Stripe (strong reducingagent): Reactivity Hazard; Store separately in an area iso-lated from flammables, combustibles, or other yellow-codedmaterials. (2) Color Code- White: Corrosive or ContactHazard; Store separately in a corrosion-resistant location.(3) Color Code- -Blue: Health Hazard/Poison: Store in asecure poison location. A regulated, marked area should beestablished where this chemical is handled, used, or storedin compliance with OSHA Standard 1910.1045. Store intightly closed containers in a cool, well-ventilated areaaway from oxidizers, bases.

Shipping

Hydrazinesulfatemustbelabeled“CORROSIVE." It falls in Hazard Class 8 and PackingGroup III.

Purification Methods

Its solubility in H2O is 3% at room temperature, but is very soluble in hot H2O. It is a suspected carcinogen. [Adams & Brown Org Synth Coll Vol I 309 1941, Audrieth & Nickles Inorg Synth I 90 1939.]

Incompatibilities

A strong reducing agent. Reacts with oxi-dizers, bases.