Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listGlibornuride

Glibornuride

  • CAS NO.:26944-48-9
  • Empirical Formula: C18H26N2O4S
  • Molecular Weight: 366.47504
  • MDL number: MFCD00869202
  • EINECS: 2481246
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-07-02 08:55:01
Glibornuride Structural

What is Glibornuride?

Originator

Glutril,Roche,W. Germany,1972

The Uses of Glibornuride

Glibornuride has been shown to antagonize the relaxant response to the K+ channel opener cromakalim and produce airway smooth muscle relaxation. Glibornuride is associated with lactic acidosis and hypoglycemia in patients with type 2 diabetes melitus.

Definition

ChEBI: Glibornuride is a monoterpenoid.

Manufacturing Process

2.1 grams of 3-endo-aminoborneol hydrochloride and 2.4 grams of O-methylN-p-toluene-sulfonyl-urea are heated at 125°C for 3 hours with 2 ml of dimethylformamide. After cooling, the reaction mixture is stirred with 100 ml of water for 10 minutes, while a pH of 3.5 is maintained by the addition of a few drops of dilute hydrochloric acid. The precipitate is removed by filtration, washed with water and suspended in 100 ml of water. The suspension is dissolved by the addition of 20 ml of 1 N caustic soda. The alkaline solution is extracted with ether, acidified with dilute hydrochloric acid and filtered. The precipitate is washed with water and recrystallized from alcohol/water to yield 1-(p-toluene-sulfonyl)-3-(2-endo-hydroxy-3-endo-bornyl)-urea having a melting point of 193° to 195°C.

brand name

Glutril (Hoffmann-LaRoche).

Therapeutic Function

Oral hypoglycemic

Properties of Glibornuride

Melting point: 192-195° (ethanol-water); also reported as 195-198°
alpha  D +63.8° (ethanol)
Density  1.1793 (rough estimate)
refractive index  1.6930 (estimate)
storage temp.  Store at -20°C
solubility  DMSO : 250 mg/mL (682.17 mM; Need ultrasonic)
pka 5.20±0.10(Predicted)
form  Solid
color  White to off-white

Safety information for Glibornuride

Computed Descriptors for Glibornuride

Related products of tetrahydrofuran

You may like

  • 26944-48-9 Glibornuride 98%
    26944-48-9 Glibornuride 98%
    26944-48-9
    View Details
  • 1-Methyl-6-oxo-1,6-dihydropyridazine-3-carbonitrile 98%
    1-Methyl-6-oxo-1,6-dihydropyridazine-3-carbonitrile 98%
    99903-60-3
    View Details
  • 1823368-42-8 98%
    1823368-42-8 98%
    1823368-42-8
    View Details
  • 2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%
    2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%
    1307449-08-6
    View Details
  • Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%
    Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%
    25408-95-1
    View Details
  • 2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%
    2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%
    1805639-70-6
    View Details
  • 1784294-80-9 98%
    1784294-80-9 98%
    1784294-80-9
    View Details
  • Lithium Clavulanate
    Lithium Clavulanate
    61177-44-4
    View Details
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.