Pioglitazone hydrochloride
Synonym(s):5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione monohydrochloride;5-[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]benzyl]thiazolidine-2,4-dione hydrochloride;Pioglitazone hydrochloride
- CAS NO.:112529-15-4
- Empirical Formula: C19H21ClN2O3S
- Molecular Weight: 392.9
- MDL number: MFCD04975446
- EINECS: 629-731-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-07 14:24:42
What is Pioglitazone hydrochloride?
Description
Pioglitazone is a new orally active thiazolidinedione (TZD) launched in the US for the treatment of non-insulin dependent diabetes mellitus (NIDDM). It can be synthesized in 4 steps, the last one transforming an alphabromoester into thiazolidine with thiourea. As with other representatives in this class, it potently activates the nuclear receptor peroxisome proliferator-activated receptor gamma which is believed to be involved in the regulation of insulin resistance and adipogenesis. In several obese and obese diabetic animal models, treatment with Pioglitazone resulted in reductions in plasma glucose and serum lipids. In clinical studies, Pioglitazone at a once daily oral dose of 15-45 mg, as monotherapy or in combination with non-TZDs or insulin, was shown to significantly improve glycemic control in type-2 diabetes and demonstrated a beneficial effect on insulin resistance and other clinically relevant parameters as plasma levels of triglycerides or HDL-cholesterol. Pioglitazone is reported to be safe and well tolerated and is said to have a lower occurrence of hepatic toxicity as well as a low probability for drug interaction.
The Uses of Pioglitazone hydrochloride
Pioglitazone hydrochloride is a euglycemic agent,used as an antidiabetic.
What are the applications of Application
Pioglitazone hydrochloride is a specific PPAR-γ ligand
Properties of Pioglitazone hydrochloride
Melting point: | 193-194°C |
storage temp. | 2-8°C |
solubility | DMSO: ≥10mg/mL |
form | powder |
color | white to off-white |
Water Solubility | Soluble in water (<1 mg/ml at 25°C), DMF, methanol, ethanol (4 mg/ml at 25°C), and DMSO (79 mg/ml at 25°C). |
Safety information for Pioglitazone hydrochloride
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for Pioglitazone hydrochloride
InChIKey | GHUUBYQTCDQWRA-UHFFFAOYSA-N |
Abamectin manufacturer
Jigs Chemical ltd
Dr. Reddy's Laboratories Ltd
KARPSCHEM LABORATORIES PVT. LTD.
Vidgas science and technologies Pvt Ltd
Nivika Chemo Pharma Pvt Ltd
Apotex Pharmachem India Pvt Ltd
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