Formamide
Synonym(s):Formamide;Formamide in dimethyl sulfoxide;Formamide solution;Formic acid amide, Methane amide;Formic amide
- CAS NO.:75-12-7
- Empirical Formula: CH3NO
- Molecular Weight: 45.04
- MDL number: MFCD00007941
- EINECS: 200-842-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-07 14:14:28
What is Formamide?
Description
Formamide, the simplest carboxylic acid amide, is a viscous, odorless, colorless liquid with a melting point of 2 oC and a boiling point of 210 oC. When it is heated to 180 oC at atmospheric pressure, however, it begins to decompose into carbon dioxide and ammonia.
In 1920, K H. Meyer and L. Orthmer discovered that formamide can be produced by heating CO2?and NH3?under pressure—the reverse of the decomposition reaction. Today, some formamide is still made this way, but the more common process uses the reaction of methyl formate with NH3. Byproduct methanol is treated with carbon monoxide to produce additional methyl formate.
Formamide is used as a feedstock in the manufacture of formate esters, as an ionizing solvent, as an RNA stabilizer in gel electrophoresis, and in tissue preservation. More intriguingly, it may be a key compound in the origin of life on Earth.
In 2014, chemist S. Civi? and co-workers at the Central European Institute of Technology (Brno, Czech Republic) simulated asteroid and meteor collisions by bombarding formamide and clay with a powerful laser. They produced (among many other compounds) guanine, adenine, cytosine, and uracil—the four nitrogen bases that make up DNA. Formamide is found in great quantities throughout the observable universe, giving credibility to the idea that life on Earth could have originated outside the planet.
The Uses of Formamide
Formamide destabilizes nucleic acid duplexes and may be used, typically, at a concentration of 50%, in hybridization protocols requiring lower hybridization temperatures.
What are the applications of Application
Formamide is an adenine deaminase inhibitor
Properties of Formamide
Melting point: | 2-3 °C(lit.) |
Boiling point: | 210 °C(lit.) |
Density | 1.134 g/mL at 25 °C(lit.) |
Flash point: | 310 °F |
storage temp. | Store at +2°C to +25°C. |
solubility | H2O: 10 M at 20 °C, clear, colorless |
form | liquid |
color | clear, colorless |
Odor | Odorless |
Water Solubility | miscible |
Sensitive | Hygroscopic |
Safety information for Formamide
Signal word | Danger |
Pictogram(s) |
Health Hazard GHS08 |
GHS Hazard Statements |
H351:Carcinogenicity H373:Specific target organ toxicity, repeated exposure |
Precautionary Statement Codes |
P202:Do not handle until all safety precautions have been read and understood. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P308+P313:IF exposed or concerned: Get medical advice/attention. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for Formamide
InChIKey | ZHNUHDYFZUAESO-UHFFFAOYSA-N |
Abamectin manufacturer
JSK Chemicals
Aarti Drugs Ltd (part of Aarti Group of Industries)
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