N-Methyl-N-(trimethylsilyl)trifluoroacetamide

Synonym(s):N-Methyl-N-(trimethylsilyl)trifluoroacetamide;N-Trimethylsilyl-N-methyl trifluoroacetamide;2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide;MSTFA;N-Methyl-N-trimethylsilyl-trifluoroacetamide

CAS NO.：24589-78-4
Empirical Formula: C6H12F3NOSi
Molecular Weight: 199.25
MDL number: MFCD00000411
EINECS: 246-331-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-17 21:30:02

N-Methyl-N-(trimethylsilyl)trifluoroacetamide Structural

What is N-Methyl-N-(trimethylsilyl)trifluoroacetamide?

Chemical properties

Clear colorless to light yellow liquid

The Uses of N-Methyl-N-(trimethylsilyl)trifluoroacetamide

N-Methyl-N-(trimethylsilyl)trifluoroacetamide is used as a silylating reagent that forms volatile derivatives for GC-MS analysis. It acts as a pharmaceutical intermediate and metabolite of Famprofazone in humans. It is also used in the detection of steroid hormones 17-alfa-ethynylestradiol and estrone.

The Uses of N-Methyl-N-(trimethylsilyl)trifluoroacetamide

A new metabolite of Famprofazone in humans.

What are the applications of Application

N-Methyl-N-(trimethylsilyl)trifluoroacetamide is silylating agent that forms volatile derivatives for GC-MS analysis

Definition

ChEBI: An N-silyl compound that is N-methyltrifluoroacetamide in which the amide nitrogen is replaced by a trimethylsilyl group. N-methyl-N-(trimethylsilyl)trifluoroacetamide is a derivat sation agent used in gas chromatography/mass spectrometry applications.

General Description

N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA) is a derivatizing reagent. It can be used as alternatives to diazomethane.

Purification Methods

Fractionate the amide through a 40mm Vigreux column (p 11). Usually it contains ca 1% of methyl trifluoroacetamide and 1% of other impurities which can be removed by gas chromatography or fractionating using a spinning band column. [Donike J Chromatogr 42 103 1969, Donike J Chromatogr 103 91 1975, Beilstein 4 IV 4011.]

Properties of N-Methyl-N-(trimethylsilyl)trifluoroacetamide

Melting point:	98-100°C
Boiling point:	130132°C
Density	1.075 g/mL at 25 °C(lit.)
vapor density	>1 (vs air)
vapor pressure	8.8 mm Hg ( 27 °C)
refractive index	n20/D 1.383
Flash point:	77 °F
storage temp.	2-8°C
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly)
pka	-1.34±0.70(Predicted)
form	Liquid
color	Clear colorless to light yellow
Specific Gravity	1.076
Water Solubility	reacts
Sensitive	Moisture Sensitive
Hydrolytic Sensitivity	7: reacts slowly with moisture/water
BRN	1941550
CAS DataBase Reference	24589-78-4(CAS DataBase Reference)
EPA Substance Registry System	Acetamide, 2,2,2-trifluoro-N-methyl-N-(trimethylsilyl)- (24589-78-4)

Safety information for N-Methyl-N-(trimethylsilyl)trifluoroacetamide

Signal word	Warning
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H226:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.