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HomeProduct name listN,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)

N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)

Synonym(s):Bisdiamine;Bis-diamine;Fertilysin;N,N′-1,8-Octanediylbis[2,2-dichloro-acetamide; N,N′-Bis(dischloroacetyl)-1,8-octamethylenediamine;

  • CAS NO.:1477-57-2
  • Empirical Formula: C12H20Cl4N2O2
  • Molecular Weight: 366.11
  • MDL number: MFCD00000841
  • EINECS: 216-033-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) Structural

What is N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)?

Chemical properties

white crystalline powder

The Uses of N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)

Win 18446 was shown to inhibit the biosynthesis of retinoic acid from retinol in neonatal and adult murine testis and in the embryonic murine gonad.

What are the applications of Application

N,N′-Octamethylenebis(2,2-dichloroacetamide) is an inhibitor of aldehyde dehydrogenase, ALDH1A2

Definition

ChEBI: A carboxamide that is 1,8-diaminooctane in which a hydrogen attached to each of the amino groups has been replaced by a dichloroacetyl group. Inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2). Inhibits the biosynthesis of retinoic acid from retinol in neon tal and adult murine testis. It down-regulates sex related genes in zebrafish.

Biological Activity

win 18446 is a bis-(dichloroacetyl)-diamine which inhibits aldehyde dehydrogenase 1a2 (aldh1a2), with ic50 value of 300 nm [1].aldh1a2, expressed almost exclusively in the testes, localizes to developing germ cells within the seminiferous tubules and strongly binds retinol, but does not recognize acetaldehyde as a substrate, suggesting that aldh1a2 functions in testicular retinoic acid biosynthesis [1].in whole testes or germ cells isolated from mice at 2 days postpartum, win 18,446 alone (1 μm) or in combination with retinol significantly reduced the expression of stra8, a marker for retinoic acid activity [2].in male rabbits, oral administration of win 18446 at 200 mg/kg for 16 weeks substantially reduced intratesticular concentrations of retinoic acid, significantly impaired spermatogenesis, and resulted in infertility. reduced concentrations of intratesticular retinoic acid became obvious after only 4 weeks of treatment and preceded the decrease in sperm counts and the loss of mature germ cells in tissue samples. sperm counts and fertility recovered after treatment was discontinued [1].[1]. amory j k, muller c h, shimshoni j a, et al. suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis. journal of andrology, 2011, 32(1): 111-119.[2]. hogarth c a, evanoff r, snyder e, et al. suppression of stra8 expression in the mouse gonad by win 18,446. biology of reproduction, 2011, 84(5): 957-965.

Safety Profile

Poison by intraperitoneal route.Human systemic effects by ingestion: nausea andvomiting. Human reproductive effects by ingestion:changes in spermatogenesis. An experimental teratogen.Other experimental reproductive effects. Human mutationdata reporte

storage

Store at +4°C

Properties of N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)

Melting point: 118-120 °C
Boiling point: 530℃
Density  0.726
refractive index  1.6200 (estimate)
Flash point: 275℃
storage temp.  Inert atmosphere,2-8°C
solubility  Acetone (Very Slightly), DMSO (Slightly), Methanol (Sparingly, Heated, Sonicated
form  Solid
pka 12.28±0.46(Predicted)
color  White to Off-White
CAS DataBase Reference 1477-57-2

Safety information for N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
GHS Hazard Statements H351:Carcinogenicity
Precautionary Statement Codes P202:Do not handle until all safety precautions have been read and understood.
P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313:IF exposed or concerned: Get medical advice/attention.

Computed Descriptors for N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)

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