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HomeProduct name listCORTISOL 17-VALERATE

CORTISOL 17-VALERATE

Synonym(s):11β,17,21-Trihydroxypregn-4-ene-3,20-dione 17-valerate;Cortisol 17-valerate;Hydrocortisone 17-valerate

  • CAS NO.:57524-89-7
  • Empirical Formula: C26H38O6
  • Molecular Weight: 446.58
  • MDL number: MFCD00083365
  • EINECS: 260-786-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 20:33:22
CORTISOL 17-VALERATE Structural

What is CORTISOL 17-VALERATE?

Absorption

Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption.

Toxicity

Side effects include inhibition of bone formation, suppression of calcium absorption and delayed wound healing

The Uses of CORTISOL 17-VALERATE

antiinflammatory, glucocorticoid

The Uses of CORTISOL 17-VALERATE

Hydrocortisone 17-Valerate is a derivative of Hydrocortisone (H714615) which is a glucocorticoid that is produced by the zona fasciculata of the adrenal gland.

Definition

ChEBI: Cortisol 17-valerate is a glucocorticoid, a cortisol ester, a valerate ester and a primary alpha-hydroxy ketone.

What are the applications of Application

Hydrocortisone 17-valerate is a derivative of hydrocortisone

Indications

For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.

brand name

Westcort (Westwood-Squibb).

Pharmacokinetics

Hydrocortisone is the most important human glucocorticoid. It is essential for life and regulates or supports a variety of important cardiovascular, metabolic, immunologic and homeostatic functions. Topical hydrocortisone is used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses. Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects. Glucocorticoids are distinguished from mineralocorticoids and sex steroids by having different receptors, target cells, and effects. Technically, the term corticosteroid refers to both glucocorticoids and mineralocorticoids, but is often used as a synonym for glucocorticoid. Glucocorticoids suppress cell-mediated immunity. They act by inhibiting genes that code for the cytokines IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8 and TNF-alpha, the most important of which is the IL-2. Reduced cytokine production limits T cell proliferation. Glucocorticoids also suppress humoral immunity, causing B cells to express lower amounts of IL-2 and IL-2 receptors. This diminishes both B cell clonal expansion and antibody synthesis. The diminished amounts of IL-2 also leads to fewer T lymphocyte cells being activated.

Metabolism

Primarily hepatic via CYP3A4

Properties of CORTISOL 17-VALERATE

Melting point: 217-220 °C
Boiling point: 595.1±50.0 °C(Predicted)
Density  1.21±0.1 g/cm3(Predicted)
storage temp.  Refrigerator, under inert atmosphere
solubility  Chloroform (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly, Heated
pka 12.98±0.10(Predicted)
form  Solid
form  neat
color  White to Off-White

Safety information for CORTISOL 17-VALERATE

Signal word Warning
Pictogram(s)
ghs
Health Hazard
GHS08
GHS Hazard Statements H351:Carcinogenicity
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for CORTISOL 17-VALERATE

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