3,20-Dioxopregn-4-en-17-beta-yl acetate

CAS NO.：17308-02-0
Empirical Formula: C23H32O4
Molecular Weight: 372.51
MDL number: MFCD00021156
EINECS: 241-337-5
SAFETY DATA SHEET (SDS)
Update Date: 2023-09-19 14:43:45

What is 3,20-Dioxopregn-4-en-17-beta-yl acetate?

The Uses of 3,20-Dioxopregn-4-en-17-beta-yl acetate

3,20-Dioxopregn-4-en-17-beta-yl acetate, also known as 17-Hydroxyprogesterone acetate, is a new steroid for oral administration. It has a progestational activity which is at least twice that of anhydrohydroxyprogesterone[1].

Mechanism of action

3,20-Dioxopregn-4-en-17-beta-yl acetate could induces secretory changes in the endometrium and luteal changes in the exfoliated vaginal epithelial cells, reduces fern-like patterns of the cervical mucus, causes a rise of basal body temperature, and induces withdrawal bleeding in castrates[1].

References

[1] Davis M, et al. 17-α-HYDROXYPROGESTERONE ACETATE; AN EFFECTIVE PROGESTATIONAL SUBSTANCE ON ORAL ADMINISTRATION. The Journal of clinical endocrinology and metabolism, 1957; 17: 1237–1244,.

Properties of 3,20-Dioxopregn-4-en-17-beta-yl acetate

Melting point:	198 °C
Boiling point:	490.2±45.0 °C(Predicted)
Density	1.14±0.1 g/cm3(Predicted)
InChI	InChI=1/C23H32O4/c1-14(24)23(27-15(2)25)12-9-20-18-6-5-16-13-17(26)7-10-21(16,3)19(18)8-11-22(20,23)4/h13,18-20H,5-12H2,1-4H3/t18-,19+,20+,21+,22+,23-/s3
CAS DataBase Reference	17308-02-0(CAS DataBase Reference)