cilengitide
- CAS NO.：188968-51-6
- Empirical Formula: C27H40N8O7
- Molecular Weight: 588.66
- MDL number: MFCD04307743
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-21 17:31:59
What is cilengitide?
The Uses of cilengitide
Cilengitide trifluoroacetic acid salt has been used as an inhibitor of integrin αvβ5.
The Uses of cilengitide
Angiogenesis inhibitor.
Definition
ChEBI: Cilengitide is an oligopeptide.
Biochem/physiol Actions
It exhibits antitumor activity in glioblastoma multiforme tumors. Integrins are heterodimers of α and β chain. They are transmembrane receptors which are responsible for cell-to-cell and cell-extracellular matrix interactions. They control tumor angiogenesis, invasion and migration.
storage
Store at -20°C
Properties of cilengitide
| Density | 1.41±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | ≥29.43 mg/mL in DMSO; ≥22.56 mg/mL in H2O |
| pka | 4.01±0.10(Predicted) |
| form | powder |
| color | white to beige |
| Water Solubility | Soluble to 10 mg/ml in water |
Safety information for cilengitide
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for cilengitide
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