BMS 833923
- CAS NO.：1059734-66-5
- Empirical Formula: C30H27N5O
- Molecular Weight: 473.57
- MDL number: MFCD25976660
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-01 18:09:03
What is BMS 833923?
Description
Smoothened (Smo) is a cell surface receptor that, with Patched, mediates sonic hedgehog (Shh) signaling to regulate gene expression through the Gli transcription factors. BMS 833923 is an orally bioavailable inhibitor of Smo. It blocks binding of BODIPY cyclopamine (IC50 = 21 nM) and inhibits Gli activation in cell lines that express wild-type Smo or activated mutant forms of Smo (IC50s = 6-35 nM). BMS 833923 robustly inhibits Shh pathway activity and prevents tumor growth in medulloblastoma and pancreatic carcinoma xenograft models.
The Uses of BMS 833923
BMS 833923 is an antagonist of smoothened, a key hedgehog (Hh) pathway regulator.
Properties of BMS 833923
| Density | 1.252±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | ≥47.4 mg/mL in DMSO; insoluble in H2O; ≥5.14 mg/mL in EtOH with gentle warming and ultrasonic |
| form | solid |
| pka | 13.42±0.70(Predicted) |
| color | Light yellow to yellow |
Safety information for BMS 833923
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for BMS 833923
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