CNX-1351
- CAS NO.：1276105-89-5
- Empirical Formula: C30H35N7O3S
- Molecular Weight: 573.71
- MDL number: MFCD25976872
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is CNX-1351?
Biological Activity
CNX-1351 is a potent and selective PI3Kα inhibitor with IC50 of 6.8 nM.
in vivo
CNX-1351 inhibits p-Akt Ser473 in mouse spleens and bonds to PI3Kα in vivo. It is delivered into the intraperitoneal cavity of nude mice at 100 mg/kg once a day for 5 consecutive days (n=3 mice per group).
Properties of CNX-1351
| Density | 1.328±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 33.33 mg/mL (58.10 mM; Need ultrasonic) |
| form | Powder |
| pka | 12.22±0.40(Predicted) |
| color | White to yellow |
Safety information for CNX-1351
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for CNX-1351
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