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HomeProduct name listCNX-1351

CNX-1351

CNX-1351 Structural

What is CNX-1351?

Biological Activity

CNX-1351 is a potent and selective PI3Kα inhibitor with IC50 of 6.8 nM.

in vivo

CNX-1351 inhibits p-Akt Ser473 in mouse spleens and bonds to PI3Kα in vivo. It is delivered into the intraperitoneal cavity of nude mice at 100 mg/kg once a day for 5 consecutive days (n=3 mice per group).

Properties of CNX-1351

Density  1.328±0.06 g/cm3(Predicted)
storage temp.  Store at -20°C
solubility  DMSO : 33.33 mg/mL (58.10 mM; Need ultrasonic)
form  Powder
pka 12.22±0.40(Predicted)
color  White to yellow

Safety information for CNX-1351

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for CNX-1351

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