Bendamustine hydrochloride
Synonym(s):1H-Benzimidazole-2-butanoic acid, 5-[bis(2-chloroethyl)amino]-1-methyl monohydrochloride;Treanda
- CAS NO.:3543-75-7
- Empirical Formula: C16H22Cl3N3O2
- Molecular Weight: 394.72
- MDL number: MFCD01658758
- EINECS: 631-540-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-25 11:16:43
What is Bendamustine hydrochloride?
Description
Bendamustine is a purine analog and DNA alkylating agent. It inhibits growth of SKW-3, Reh, CML-T1, BV-173, and HL-60 leukemia cell lines (IC50s = 27.0, 28.6, 15.6, 20.8, and 57.7 μM, respectively) but not MCF-7 and MDA-MB-231 breast cancer cell lines (IC50s = >200 and >200 μM, respectively). It kills B cell-chronic lymphocytic leukemia (B-CLL) cells derived from naïve and bendamustine-pretreated patients (LD50s = 6.8-8.3 and 3.8-4.9 mg/ml, respectively). Bendamustine (50 mg/kg) inhibits tumor growth by 9% and 96% alone and in combination with ofatumumab, respectively, in a JVM-3 CLL mouse xenograft model. It activates the DNA-damage stress response, the base excision DNA repair pathway, and apoptosis, as well as inhibits mitotic checkpoints and induces mitotic catastrophe. Formulations containing bendamustine have been used to treat CLL and non-Hodgkin lymphoma.
The Uses of Bendamustine hydrochloride
Bendamustine hydrochloride hydrate has been used as:
- a chemotherapy agent for chronic lymphocytic leukemia (CLL) samples to monitor spliced and unspliced gene expression
- an inhibitor to E3 ubiquitin-protein ligase RNF3 (HOIP) in?matrix-assisted laser desorption ionization time-of-flight mass spectrometry?(MALDI-TOF) assay
- a cytotoxic chemotherapeutic drug in high-throughput screening to test interaction with BAY87-2243
What are the applications of Application
Bendamustine Hydrochloride is a nitrogen mustard purine analog alkylator
Properties of Bendamustine hydrochloride
Melting point: | 149-151°C |
storage temp. | room temp |
solubility | H2O: >30mg/mL |
form | powder |
color | off-white |
Safety information for Bendamustine hydrochloride
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 |
GHS Hazard Statements |
H301:Acute toxicity,oral H341:Germ cell mutagenicity H351:Carcinogenicity |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for Bendamustine hydrochloride
InChIKey | ZHSKUOZOLHMKEA-UHFFFAOYSA-N |
Abamectin manufacturer
SGMR PHARMACEUTICALS PVT LTD
Dr. Reddy's Laboratories Ltd
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Vannsh Life Sciences Pvt Ltd
Aavyan Labs
Salvavidas Pharmaceutical Pvt., Ltd.
Basil Drugs AND Pharmaceuticals Pvt Ltd
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