AROTINOLOL
- CAS NO.:68377-92-4
- Empirical Formula: C15H21N3O2S3
- Molecular Weight: 371.54
- MDL number: MFCD00865895
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:19
What is AROTINOLOL?
Originator
Arotinolol,ZYF Pharm
The Uses of AROTINOLOL
Arotinolol is both and alpha- and beta-adrenoceptor antagonist and is used to treat essential tremors and hypertension.
Definition
ChEBI: Arotinolol is a member of thiophenes and an aromatic amide.
Manufacturing Process
To a solution of 2-mercapto-4-(5'-carbamoyl-2'-thiophenyl)thiazole, 3.2 g in
20 ml of 0.3 % aqueous sodium hydroxide solution, 1-chloro-3-tbutylaminopropanol,
12.64 g in 20 ml of methanol was added, while the
temperature was maintained at 20°C.
The reaction solution was stirred at room temperature for 4 h, and then
condensed to a half volume in vacuo. The residual solution, added with 100 ml
of water, was extracted with chloroform. The chloroform extract was washed
with water, dried over anhydrous magnesium sulfate and evaporated in vacuo
to give 4.8 g of 2-(3'-t-butylamino-2'-hydroxypropylthio)-4-(5'-carbamoyl-2'-
thiophenyl)thiazole, as crystals, melting point 234°-235.5°C (dec.,
recrystallized from methanol/water).
In practice it is usually used as hydrochloride.
Therapeutic Function
Beta-adrenergic blocker
Properties of AROTINOLOL
Melting point: | 148-149° |
Boiling point: | 599.8±60.0 °C(Predicted) |
Density | 1.35 |
storage temp. | 2-8°C(protect from light) |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 13.71±0.20(Predicted) |
color | Off-White to Pale Yellow |
Safety information for AROTINOLOL
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for AROTINOLOL
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