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HomeProduct name listAmmonium thioglycolate

Ammonium thioglycolate

Synonym(s):Thioglycolic acid ammonium salt

  • CAS NO.:5421-46-5
  • Empirical Formula: C2H7NO2S
  • Molecular Weight: 109.15
  • MDL number: MFCD00137451
  • EINECS: 226-540-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-06 16:09:44
Ammonium thioglycolate  Structural

What is Ammonium thioglycolate ?

Description

Ammonium thioglycolate, also known as perm salt, is the chemical compound with the formula HSCH2CO2NH4. Being the salt of a weak acid and weak base, ammonium thioglycolic acid exists in solution as an equilibrium mixture of the salt itself as well as the free carboxylic acid thioglycolic acid (HSCH2CO2H) and ammonia : HSCH2COO- + NH4+ ? HSCH2COOH + NH3.

Chemical properties

Clear colorless solution with characteristic odor

The Uses of Ammonium thioglycolate

Ammonium thioglycolate is contained in permanent waves solutions and causes contact dermatitis in hairdressers.

The Uses of Ammonium thioglycolate

Solutions of various strengths are used for hair waving and for hair removal.

The Uses of Ammonium thioglycolate

acts as a reducing agent in permanent-waving formulations for hair treatment and in shrink-resistant treatment of wool.

Definition

ChEBI: Ammonium thioglycolate is an organic ammonium salt having thioglycolate(1-) as the counterion. Also known as perm salt, it has use in perming hair. It has a role as a reducing agent and an allergen. It contains a thioglycolate(1-).

General Description

Colorless to faint pink liquid with a repulsive, skunk-like odor.

Air & Water Reactions

Water soluble.

Reactivity Profile

Ammonium thioglycolate may be sensitive to heat. Ammonium thioglycolate is incompatible with acids.

Fire Hazard

Flash point data for Ammonium thioglycolate are not available. Ammonium thioglycolate is combustible.

Flammability and Explosibility

Not classified

Contact allergens

This substance is contained in “basic” permanent waves solutions and causes contact dermatitis in hairdressers.

Safety Profile

Poison by intravenous and intraperitoneal routes. An allergen; can cause contact dermatitis. Emits hydrogen sulfide. See also SULFIDES. When heated to decomposition it emits very toxic NOx, SOx, and NH3.

Chemical concepts related to perms

When discussing the chemistry of perms, one should consider two chemical facts. First is the thiol-disulfide equilibrium:
RSH + R'SSR' ? R'SH + RSSR'
where R and R' are organic substituents such as methyl (-CH3), ethyl (-C2H5), or -CH2COO-.
The thiol-disulfide exchange reaction is accelerated by bases such as ammonia, because the base generates some thiolate anion (RS- ), which attacks the disulfide. Thus the ammonia plays multiple roles (and more, see below) in this application.
The second chemical fact is that polar molecules are less volatile than nonpolar ones. So the glycolate substituent makes the thiol nonvolatile and hence non-odorous. An added advantage is that the glycolate confers some solubility in water. One could almost certainly use HSCH3 and ammonia to give a perm, but there would be serious olfactory consequences.

The actual chemistry of perms

A solution containing ammonium thioglycolate contains a lot of free ammonia, which swells hair, rendering it permeable. The thioglycolic acid in the perm solution reduces the disulfide cystine bonds in the cortex of the hair. In a sense, the thioglycolate removes crosslinks. After washing, the hair is treated with a mild solution of hydrogen peroxide, which oxidizes the cysteines back to cystine. These new chemical bonds impart the structural rigidity necessary for a successful perm. The rigidification process is akin to the vulcanization of rubber, where commonly polysulfide linkages are used to crosslink the polymer chains. However, not as many disulfide bonds are reformed as there were before the permanent. As a result, the hair is weaker than before the permanent was applied and repeated applications over the same spot may eventually cause strand breakage.

Properties of Ammonium thioglycolate

Melting point: 139-139.5 °C
Boiling point: 115℃[at 101 325 Pa]
Density  1.22
vapor pressure  0.001Pa at 25℃
form  Solution
color  Clear colorless
Specific Gravity 1.245 (25℃)
Odor strong skunk-like odor
Water Solubility  Miscible
InChI InChI=1S/C2H4O2S.H3N/c3-2(4)1-5;/h5H,1H2,(H,3,4);1H3
CAS DataBase Reference 5421-46-5(CAS DataBase Reference)
EPA Substance Registry System Acetic acid, 2-mercapto-, ammonium salt (1:1) (5421-46-5)

Safety information for Ammonium thioglycolate

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H290:Corrosive to Metals
H301:Acute toxicity,oral
H317:Sensitisation, Skin
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.

Computed Descriptors for Ammonium thioglycolate

InChIKey JYAVWXRMOOCSOD-UHFFFAOYSA-N
SMILES C([O-])(=O)CS.[NH4+]

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